Transmission of BSE by blood transfusion in sheep
Transmission of BSE by blood transfusion in sheep
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DOI：
10.1016/s0140-6736(00)02719-7
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发表时间：
2000-09-16
期刊：
影响因子：
168.9
通讯作者：
Bostock, CJ
中科院分区：
文献类型：
--
作者：
Houston, F;Foster, JD;Bostock, CJ
我们已经证明，牛海绵状脑病（BSE）有可能通过在实验性BSE感染的无症状阶段从另一只羊身上取全血输血而传播给羊。疯牛病与人类变异型克雅氏病（vCJD）是由相同的传染因子引起的，羊-疯牛病实验模型与人类vCJD的发病机制相似。虽然输血是一种可能防止血液传播风险的保护措施，但该报告表明，无症状的vCJD感染者捐献的血液可能代表了vCJD感染在英国人群中传播的风险。
We have shown that it is possible to transmit bovine spongiform encephalopathy (BSE) to a sheep by transfusion with whole blood taken from another sheep during the symptom-free phase of an experimental BSE infection. BSE and variant Creutzfeldt-Jakob disease (vCJD) in human beings are caused by the same infectious agent, and the sheep-BSE experimental model has a similar pathogenesis to that of human vCJD. Although Uh blood transfusions ale leucodepleted-a possible protective measure against any risk from blood transmission-this report suggests that blood donated by symptom-free vCJD-infected human beings may represent a risk of spread of vCJD infection among the human population of the UK.