Ethanol and NMDA receptor signaling.
Ethanol and NMDA receptor signaling.
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DOI：
10.1080/08913810008443548
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
J. Woodward
中科院分区：
文献类型：
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作者：
J. Woodward
NMDA受体是由神经递质谷氨酸激活的离子型受体的多亚基家族。主要定位于神经元突触后，它们在介导兴奋性突触神经传递中起重要作用，并涉及各种重要的钙依赖性神经元过程。表达NMDA亚基突变形式的实验动物表现出异常的行为和运动及认知障碍。在过去的10年中，大量的研究表明，NMDA受体是乙醇在大脑中的重要作用部位。本文讨论了急性乙醇对NMDA受体功能的影响，特别关注定义乙醇对受体作用的分子位点的努力。虽然很明显NMDA受体的乙醇敏感性受亚基组成的影响，但也很明显，翻译后因子如磷酸化和蛋白质-蛋白质相互作用在调节这种敏感性中很重要。
NMDA receptors are a multi-subunit family of ionotropic receptors activated by the neurotransmitter glutamate. Localized primarily postsynaptically in neurons, they play an important role in mediating excitatory synaptic neurotransmission and are implicated in a wide variety of important calcium-dependent neuronal processes. Experimental animals expressing mutant forms of NMDA subunits display abnormal behaviors and locomotor and cognitive impairments. Over the last 10 years, a wealth of studies has indicated that NMDA receptors are an important site of action for ethanol in the brain. The effects of acute ethanol on NMDA receptor function is discussed herein, with particular focus on efforts to define a molecular site of action of ethanol on the receptor. While it is clear that the ethanol sensitivity of NMDA receptors is influenced by subunit composition, it is also apparent that posttranslational factors such as phosphorylation and protein-protein interactions are important in modulating this sensitivity.