Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating
Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating
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DOI：
10.1186/1744-9081-7-45
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发表时间：
2011-10-18
影响因子：
5.1
通讯作者：
Perlmutter, Joel
中科院分区：
文献类型：
--
作者：
Nopoulos, Peg;Epping, Eric A.;Perlmutter, Joel
三联体重复导致行为特征的正常变异，当扩大时，会导致大脑紊乱。虽然已知亨廷顿氏病是由亨廷顿基因中的CAG三联体重复引起的，但CAG重复对疾病阈值以下的大脑功能的影响尚未被研究。目前的研究表明，在健康受试者中，母亲和父亲亨廷顿基因等位基因的CAG重复长度之间存在显著的相关性，提示存在配对交配。
Triplet repeats contribute to normal variation in behavioral traits and when expanded, cause brain disorders. While Huntington's Disease is known to be caused by a CAG triplet repeat in the gene Huntingtin, the effect of CAG repeats on brain function below disease threshold has not been studied. The current study shows a significant correlation between the CAG repeat length of the maternal and paternal allele in the Huntingtin gene among healthy subjects, suggesting assortative mating.