FACTORS AFFECTING THE INTENSITY OF REINFECTION WITH SCHISTOSOMA-HAEMATOBIUM FOLLOWING TREATMENT WITH PRAZIQUANTEL
FACTORS AFFECTING THE INTENSITY OF REINFECTION WITH SCHISTOSOMA-HAEMATOBIUM FOLLOWING TREATMENT WITH PRAZIQUANTEL
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DOI：
10.1017/s0031182000060364
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发表时间：
1991-02-01
期刊：
影响因子：
2.4
通讯作者：
BRADLEY, M
中科院分区：
文献类型：
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作者：
CHANDIWANA, SK;WOOLHOUSE, MEJ;BRADLEY, M
在津巴布韦东部一个约有500人的农村社区对埃及血吸虫感染进行了研究。 感染的总患病率，尿虫卵计数确定，为40.1%，和严重感染（大于或等于50个鸡蛋/10毫升尿）为11.0%。 8至10岁年龄组的重度感染和所有感染的流行率最高。 在1987-88年期间，从102名患者中获得了吡喹酮治疗14周后再感染强度的数据，4周后确定了治疗效果。 记录这些个体在处理后立即进行的2周期间的水接触。 专利感染的中间宿主蜗牛，球泡螺的相对丰度，也进行了监测。 一个指数的暴露是加权每一个水接触的持续时间，活动的类型，一天中的时间，和大量的感染蜗牛在使用的网站。 研究了再感染率、暴露率和年龄之间的关系。 虽然只有13个人表现出阳性率的再感染，有统计学意义和独立的影响，暴露和年龄的再感染率。 对再感染率的定量估计表明，12岁或以下的人比12岁以上的人获得了更多的感染（以产蛋量衡量）。
Infection with Schistosoma haematobium was studied in a rural community of approximately 500 persons in eastern Zimbabwe. The overall prevalence of infection, as determined by urine egg counts, was 40.1 %, and of heavy infections (greater-than-or-equal-to 50 eggs/10 ml urine) was 11.0 %. The prevalence of both heavy and all infections was highest in the 8 to 10-year-old age class. During 1987-88 data were obtained from 102 individuals on intensity of reinfection 14 weeks after treatment with praziquantel, the efficacy of treatment having been determined after 4 weeks. The water contact made by these individuals during 2-week periods immediately following treatment was recorded. The relative abundance of patent infected intermediate host snails, Bulinus globosus, was also monitored. An index of exposure was developed which weighted each water contact by its duration, the type of activity, the time of day, and the abundance of infected snails at the site used. The relationships between rates of reinfection, rates of exposure, and age were examined. Although only 13 individuals showed positive rates of reinfection, there were statistically significant and independent effects of both exposure and age on reinfection rate. Quantitative estimates of reinfection rates suggested that individuals aged 12 years or less acquired substantially more infection (measured as egg output) than individuals more than 12 years old.