Prospective, randomized, controlled study of in vitro fertilization-embryo transfer with a single dose of a luteinizing hormone-releasing hormone (LH-RH) antagonist (cetrorelix) or a depot formula of an LH-RH agonist (triptorelin)
Prospective, randomized, controlled study of in vitro fertilization-embryo transfer with a single dose of a luteinizing hormone-releasing hormone (LH-RH) antagonist (cetrorelix) or a depot formula of an LH-RH agonist (triptorelin)
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DOI：
10.1016/s0015-0282(99)00524-5
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发表时间：
2000-02-01
影响因子：
6.7
通讯作者：
Frydman, R
中科院分区：
文献类型：
--
作者：
Olivennes, F;Belaisch-Allart, J;Frydman, R
目的：探讨单次给药3mg头孢瑞克对早期黄体生成素激增的预防作用。设计：多中心随机、前瞻性研究。单位：生殖医学单位。患者：接受IVF-ET卵巢刺激的不孕症患者。干预措施：在卵泡晚期给予单剂量3mg的cetrorelix (Cetrotide; ASTA Medica, FrankFurt, Germany)（115例患者）。选择triptorelin （Decapeptyl; Ipsen-Biotech, Paris, France）的仓库制剂作为对照剂（39例患者）。使用hMG （Menogon; Ferring, Kiel, Germany）进行卵巢刺激。主要观察指标：黄体生成素过早增高（黄体生成素水平bbb10 IU/L），黄体酮水平大于1ng /L， NF结果。结果：给药后未出现LH增高。头孢瑞克组患者卵母细胞和胚胎数量较低。两组的成熟卵母细胞百分率和受精率相似，妊娠率无统计学差异。cetrorelix组刺激时间、给药剂量和卵巢过度刺激综合征发生率均较低。cetrorelix耐受性良好。结论：cetrorelix单剂量方案可防止所有患者LH激增。它比“长方案”更有利，可能是IVF-ET的首选方案。[j] .中国农业科学（英文版）；2000;33(3):314- 319。(C)2000年，美国生殖医学学会。
Objective: To confirm the value of a single dose of 3 mg of cetrorelix in preventing the occurrence of premature LH surges.Design: Multicenter randomized, prospective study.Setting: Reproductive medicine units.Patient(s): Infertile patients undergoing ovarian stimulation for IVF-ET.Intervention(s): A single dose of 3 mg of cetrorelix (Cetrotide; ASTA Medica, FrankFurt, Germany) (115 patients) was administered in the late follicular phase. A depot preparation of triptorelin (Decapeptyl; Ipsen-Biotech, Paris, France) was chosen as a control agent (39 patients). Ovarian stimulation was conducted With hMG (Menogon; Ferring, Kiel, Germany).Main Outcome Measure(s): Premature LH surges (LH level >10 IU/L), progesterone level greater than 1 ng/L, and NF results.Result(s): No LH surge occurred after cetrorelix administration. The patients in the cetrorelix group had a lower number of oocytes and embryos. The percentage of mature oocytes and fertilization rates were similar in both groups, and the pregnancy rates were not statistically different. The length of stimulation, number of hMG ampules administered, and occurrence of the ovarian hyperstimulation syndrome were lower in the cetrorelix group. Tolerance of cetrorelix was excellent.Conclusion(s): A cetrorelix single-dose protocol prevented LH surges in all patients studied. It compares favorably to the "long protocol" and could be a protocol of choice in IVF-ET. (Fertil Steril(R) 2000;73:314-20. (C)2000 by American Society for Reproductive Medicine.).