Global and regional gray matter reductions in ADHD:: A voxel-based morphometric study
Global and regional gray matter reductions in ADHD:: A voxel-based morphometric study
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DOI：
10.1016/j.neulet.2005.07.020
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发表时间：
2005-12-02
影响因子：
2.5
通讯作者：
Bulbena, A
中科院分区：
文献类型：
--
作者：
Carmona, S;Vilarroya, O;Bulbena, A
注意缺陷多动障碍(ADHD)是一种以注意力不集中、运动多动和冲动为特征的发育障碍。根据神经成像数据，ADHD背后的神经底物似乎涉及额纹状体回路和小脑。然而，不同的研究之间存在着重要的差异，可能是由于使用了不同的技术。这项研究的目的是使用基于体素的形态计量学方法检测一组ADHD儿童的大脑灰质(GM)和白质(WM)的异常。样本包括25名DSM-IV诊断为ADHD的儿童/青少年(药物治疗，年龄6-16岁)，并与25名健康志愿者儿童/青少年进行比较。与对照组相比，ADHD患者的大脑平均体积减少了5.4%。此外，在左额顶区(左侧运动、运动前和躯体感觉皮质)、左侧扣带回(前/中/后扣带回)、顶叶(双侧楔前叶)、颞叶(右侧颞中回、左侧海马旁回)和小脑(双侧后部)也有区域性的影响。ADHD儿童与正常儿童的WM体积无明显差异。这一结果与之前使用不同技术的研究结果一致，可能代表了ADHD中常见的一些运动和注意力缺陷的神经基础。(C)2005爱思唯尔爱尔兰有限公司。保留所有权利。
Attention deficit hyperactivity disorder (ADHD) is a developmental disorder characterized by inattentiveness, motor hyperactivity and impulsivity. According to neuroimaging data, the neural substrate underlying ADHD seems to involve fronto-striatal circuits and the cerebellum. However, there are important discrepancies between various studies, probably due to the use of different techniques. The aim of this study is to examine cerebral gray (GM) and white (WM) matter abnormalities in a group of ADHD children using a voxel-based morphometry protocol. The sample consisted of 25 children/adolescents with DSM-IV TR diagnosis of ADHD (medicated, aged 6-16 years) who were compared with 25 healthy volunteer children/adolescents. ADHD brains on an average showed a global volume decrease of 5.4% as compared to controls. Additionally, there were regionally specific effects in the left fronto-parietal areas (left motor, premotor and somatosensory cortex), left cingulate cortex (anterior/middle/posterior cingulate), parietal lobe (precuneus bilaterally), temporal cortices (right middle temporal gyrus, left parahippocampal gyrus), and the cerebellum (bilateral posterior). There were no differences in WM volume between ADHD children and control subjects. The results are consistent with previous studies that used different techniques, and may represent a possible neural basis for some of the motor and attentional deficits commonly found in ADHD. (C) 2005 Elsevier Ireland Ltd. All rights reserved.