Potentiating effect of tyramine on acetaldehyde-induced vasoconstriction in isolated dog mesenteric arteries.
Potentiating effect of tyramine on acetaldehyde-induced vasoconstriction in isolated dog mesenteric arteries.
复制标题
酪胺对乙醛诱导的离体狗肠系膜动脉血管收缩的增强作用。
DOI：
10.1254/jjp.44.365
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
M. Tsukada
中科院分区：
文献类型：
--
作者：
S. Chiba;M. Tsukada
采用不锈钢插管插入法研究乙醛对离体和灌注犬肠系膜动脉的影响。管腔内注射乙醛会引起明显的血管收缩，但重复注射乙醛会引起快速耐受。乙醛诱导的血管收缩可被 α-1 肾上腺素受体拮抗剂布那佐嗪阻断。酪胺治疗后，乙醛引起的收缩持续暂时恢复。表明酪胺可能诱导去甲肾上腺素主要从囊泡释放到神经元细胞质，乙醛可能导致去甲肾上腺素从细胞质释放到离体犬肠系膜动脉的细胞外空间。
The stainless steel cannula inserting method was used to investigate the effects of acetaldehyde on isolated and perfused dog mesenteric arteries. Acetaldehyde when intraluminally administered induced a marked vasoconstriction, but repetitive injections of acetaldehyde caused tachyphylaxis. Acetaldehyde-induced vasoconstrictions were blocked by bunazosin, an alpha-1 adrenoceptor antagonist. After tyramine treatment, the acetaldehyde-induced constriction was consistently restored temporarily. It is suggested that tyramine may induce a release of norepinephrine mostly from the vesicle to the neuronal cytosol, and acetaldehyde may cause a release of norepinephrine from the cytosol to the extracellular space in the isolated canine mesenteric artery.