A GENETIC-MAP OF THE MOUSE WITH 4,006 SIMPLE SEQUENCE LENGTH POLYMORPHISMS
A GENETIC-MAP OF THE MOUSE WITH 4,006 SIMPLE SEQUENCE LENGTH POLYMORPHISMS
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DOI：
10.1038/ng0694supp-220
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发表时间：
1994-06-01
期刊：
影响因子：
30.8
通讯作者：
LANDER, ES
中科院分区：
文献类型：
--
作者：
DIETRICH, WF;MILLER, JC;LANDER, ES
我们构建了一个包含4，006个简单序列长度多态性（SSLP）的小鼠基因组遗传图谱。该图谱提供了标记之间0.35厘摩（cM）的平均间距，对应于约750kb。大约90%的基因组位于标记的1.1 cM内，99%位于2.2 cM内。这些标记在实验室菌株之间的杂交中具有50%的平均多态性率。这些标记物在整个基因组中以相对均匀的方式分布，尽管可以检测到与随机性的一些偏差。特别是，X染色体上的标记存在显著的代表性不足。该图谱代表了我们开发包含6，000个SSLP的小鼠遗传图谱目标的三分之二点。
We have constructed a genetic map of the mouse genome containing 4,006 simple sequence length polymorphims (SSLPs). The map provides an average spacing of 0.35 centiMorgans (cM) between markers, corresponding to about 750 kb. Approximately 90% of the genome lies within 1.1 cM of a marker and 99% lies within 2.2 cM. The markers have an average polymorphism rate of 50% in crosses between laboratory strains. The markers are distributed in a relatively uniform fashion across the genome, although some deviations from randomness can be detected. In particular, there is a significant underrepresentation of markers on the X chromosome. This map represents the two-thirds point toward our goal of developing a mouse genetic map containing 6,000 SSLPs.