X and Y Chromosome Complement Influence Adiposity and Metabolism in Mice
X and Y Chromosome Complement Influence Adiposity and Metabolism in Mice
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DOI：
10.1210/en.2012-2098
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发表时间：
2013-03-01
期刊：
影响因子：
4.8
通讯作者：
Arnold, Arthur P.
中科院分区：
文献类型：
--
作者：
Chen, Xuqi;McClusky, Rebecca;Arnold, Arthur P.
研究了三种不同模型的MF 1品系小鼠，以测量性腺分泌物和性染色体类型和数量对体重和组成的影响，以及对相关代谢变量（如葡萄糖稳态、摄食和活动）的影响。3种遗传模型以不同的方式改变性染色体补体，如下：1）“四个核心基因型”小鼠，包括XX和XY性腺雄性，以及XX和XY性腺雌性; 2）XY* 模型，包括类似于XO、XX、XY和XXY的组;和3）新模型，包括具有XO、XX和XY染色体的6个组，具有睾丸或卵巢。在性腺完整的小鼠中，性腺男性比性腺女性重，但性染色体补体也影响体重。雄性/雌性差异被成年性腺切除术消除，之后具有2条性染色体（XX或XY）的小鼠具有比具有1条X染色体的小鼠更大的体重和体脂百分比。第二性染色体的任何一种类型，X或Y，有类似的效果，这表明2个性染色体各自拥有的因素，影响体重和组成的MF 1遗传背景。性染色体补体也影响代谢变量，如食物摄入量和葡萄糖耐量。结果揭示了Y染色体在代谢中的作用，不依赖于睾丸和性腺激素，并指出少数具有相似编码序列的X-Y基因对作为引起这些效应的候选者。（内分泌学154：1092-1104，2013）
Three different models of MF1 strain mice were studied to measure the effects of gonadal secretions and sex chromosome type and number on body weight and composition, and on related metabolic variables such as glucose homeostasis, feeding, and activity. The 3 genetic models varied sex chromosome complement in different ways, as follows: 1) "four core genotypes" mice, comprising XX and XY gonadal males, and XX and XY gonadal females; 2) the XY* model comprising groups similar to XO, XX, XY, and XXY; and 3) a novel model comprising 6 groups having XO, XX, and XY chromosomes with either testes or ovaries. In gonadally intact mice, gonadal males were heavier than gonadal females, but sex chromosome complement also influenced weight. The male/female difference was abolished by adult gonadectomy, after which mice with 2 sex chromosomes (XX or XY) had greater body weight and percentage of body fat than mice with 1 X chromosome. A second sex chromosome of either type, X or Y, had similar effects, indicating that the 2 sex chromosomes each possess factors that influence body weight and composition in the MF1 genetic background. Sex chromosome complement also influenced metabolic variables such as food intake and glucose tolerance. The results reveal a role for the Y chromosome in metabolism independent of testes and gonadal hormones and point to a small number of X-Y gene pairs with similar coding sequences as candidates for causing these effects. (Endocrinology 154: 1092-1104, 2013)