Guided-mode resonance sensor system for early detection of ovarian cancer
Guided-mode resonance sensor system for early detection of ovarian cancer
复制标题
用于早期检测卵巢癌的导模共振传感器系统
DOI：
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
R. Magnusson
中科院分区：
文献类型：
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作者：
D. Wawro;P. Koulen;Yiwu Ding;S. Zimmerman;R. Magnusson
一种高精度传感器系统已经开发出来，可以近乎瞬时地检测生物标志物蛋白作为卵巢浆液性乳头状癌的指标。这些高分辨率传感器基于光子导模共振技术，采用多个共振峰来快速测试复杂生物样品中的相关蛋白质。这种无标记传感器方法需要最少的样品处理，并且能够同时实时测量多种试剂。已开发出检测系统并对其性能进行了表征。将介绍血液和血清中作为卵巢癌指标上调或下调的蛋白质生物标志物的鉴定和定量。
A high-accuracy sensor system has been developed that provides near-instantaneous detection of biomarker proteins as indicators of ovarian serous papillary carcinoma. Based upon photonic guided-mode resonance technology, these highresolution sensors employ multiple resonance peaks to rapidly test for relevant proteins in complex biological samples. This label-free sensor approach requires minimal sample processing and has the capability to measure multiple agents simultaneously and in real time. A detection system has been developed and performance characterized. Identification and quantification of protein biomarkers that are up- or downregulated in blood and serum as indicators of ovarian cancer will be presented.