Lateral ridge augmentation by the use of grafts comprised of autologous bone or a biomaterial.: An experiment in the dog
Lateral ridge augmentation by the use of grafts comprised of autologous bone or a biomaterial.: An experiment in the dog
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DOI：
10.1034/j.1600-051x.2002.291213.x
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发表时间：
2002-12-01
影响因子：
6.7
通讯作者：
Lindhe, J
中科院分区：
文献类型：
--
作者：
Araújo, MG;Sonohara, M;Lindhe, J
目的：本研究旨在确定Bio-Ossa（R）块作为高嵌移植物是否可以作为新骨形成的支架材料。材料和方法：5只杂种犬。拔除下颌前磨牙。在下颌骨两侧，切除颊骨板，产生约25 mm长，8 mm高，5 mm宽的缺损。愈合3个月后，进行第二次手术。在左侧，将Bio-Oss（R）块调整到颊骨壁。移植物呈圆柱形，用微型螺钉固定，并覆盖胶原膜。在下颌骨的对侧，首先从升支获得块活检。该骨移植物具有直径为8 mm且厚度为3 mm的圆柱体形状。将移植物转移到实验部位，调整到颊壁，用微螺钉固定，并用膜覆盖。将皮瓣重新定位并缝合，以确保完全覆盖实验部位。愈合6个月后，处死犬并解剖实验部位。对活检进行处理以进行地面切片。切片在甲苯胺蓝染色，在显微镜下检查，和一些histo-和形态测定assessments made.Results：该研究表明，皮质骨作为一个高嵌体移植在侧面的牙槽嵴，在6个月的愈合期与宿主骨整合，但进行了显着的周边吸收。因此，近30%的高度和50%的移植物长度被结缔组织替代。有人进一步观察到，而含有松质骨骨矿物质的支架的移植物的尺寸保持不变，只有适量的新骨形成在该graft.Conclusion的基础上：自体皮质骨的移植物，放置在一个壁缺损的表面上，可能会在愈合过程中发生显着的再吸收。类似的Bio-Oss（R）移植物可以保持其尺寸，并且生物材料内将形成有限数量的新骨。
Objective: The present investigation was performed to determine if a block of Bio-Ossa(R) used as an onlay graft can be used as a scaffold for new bone formation.Material and methods: Five mongrel dogs were used. The mandibular premolars were extracted. On both sides of the mandible, the buccal bone plate was resected and defects, about 25 mm long, 8 mm high and 5 mm wide, were produced After 3 months of healing, a second surgical procedure was performed. In the left side, a block of Bio-Oss(R) was adjusted to the buccal bone wall. The graft had the shape of a cylinder and was retained with a miniscrew and covered with a collagen membrane. In the contra-lateral side of the mandible, a block biopsy was first obtained from the ascending ramus. This bone graft had the shape of a cylinder that was 8 mm in diameter and 3 mm thick. The graft was transferred to the experimental site, adjusted to the buccal wall, retained with a miniscrew, and covered with a membrane. The flaps were repositioned and closed with sutures to ensure a complete coverage of the experimental sites. After 6 months of healing, the dogs were sacrificed and the experimental sites dissected. The biopsies were processed for ground sectioning. The sections were stained in toluidine blue, examined in the microscope, and a number of histo- and morphometric assessments made.Results: The study demonstrated that cortical bone used as an onlay graft in the lateral aspect of the alveolar ridge, during a 6-month period of healing integrated with the host bone but underwent marked peripheral resorption. Thus, close to 30% of the height and 50% of the length of the graft was replaced with connective tissue. It was further observed that while the dimensions of a graft which contained a scaffold of cancellous bovine bone mineral remained unchanged, only moderate amounts of new bone formed at the base of this graft.Conclusion: Grafts of autologous cortical bone, placed on the surface of a one-wall defect, may undergo marked resorption during healing. A similar graft of Bio-Oss(R) may retain its dimension, and limited amounts of new bone will form within the biomaterial.