Allergy in Children in Hand Versus Machine Dishwashing Antibiotics in Fetal and Early Life and Subsequent Childhood Asthma: Nationwide Population Based Study With Sibling Analysis
Allergy in Children in Hand Versus Machine Dishwashing Antibiotics in Fetal and Early Life and Subsequent Childhood Asthma: Nationwide Population Based Study With Sibling Analysis
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胎儿和早期生命中手用抗生素与机洗抗生素的儿童过敏以及随后的儿童哮喘：基于全国人口的兄弟姐妹分析研究
DOI：
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
K. Ahn
中科院分区：
文献类型：
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作者：
Y. Park;So;W. Kim;M. Han;Jihyun Kim;Y. Chae;M. Hahm;Kee;H. Kwon;K. Park;J. Park;K. Ahn
评论员评论。这项研究是独一无二的，它试图检查婴儿期生物污染物暴露对生活在不同郊区环境中的儿童在童年后期哮喘结局的影响。然而，它的结果不一致，在1个队列中，内毒素与6岁时当前哮喘的几率增加有关，而在另一个队列中，它与10岁时医生诊断的哮喘的几率降低有关。这种不一致可能与几个因素有关。PIAMA队列的灰尘样本仅取自特应性母亲的孩子。此外，灰尘样本仅在婴儿期的一个时间点收集，尽管人们承认资源可能限制样本的确定频率。暴露时间和剂量的变化可以解释这些差异，但合并多个队列数据的概念是可取的。
REVIEWER COMMENTS. This study was unique in its attempt examine the impact of bio-contaminant exposure in infancy with asthma outcomes in later childhood in children living in diverse suburban environments. However it has inconsistent results where in 1 cohort endotoxin was associated with increased odds of current asthma at 6 years of age, whereas in another cohort, it was associated with decreased odds of doctor-diagnosed asthma ever at 10 years of age. This inconsistency could be related to several factors. The PIAMA cohort dust samples were taken only from children of atopic mothers. In addition, the dust samples were only collected at 1 time-point in infancy, although it is acknowledged that resources can limit how often samples can be ascertained. Variations in timing and dose of exposure can account for these differences, but the concept of combining data from multiple cohorts is desirable.