STUDIES ON CHEMOTHERAPEUTICS .1. SYNTHESIS OF 5-SUBSTITUTED-4-OXO-1,4-DIHYDRO-3-PYRIDINECARBOXYLIC ACID-DERIVATIVES
STUDIES ON CHEMOTHERAPEUTICS .1. SYNTHESIS OF 5-SUBSTITUTED-4-OXO-1,4-DIHYDRO-3-PYRIDINECARBOXYLIC ACID-DERIVATIVES
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DOI：
10.1002/jhet.5570170229
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发表时间：
1980-01-01
影响因子：
2.4
通讯作者：
DVORTSAK, P
中科院分区：
文献类型：
--
作者：
BALOGH, M;HERMECZ, I;DVORTSAK, P
在乙醇钠存在下，1，3，5-三嗪与4-取代乙酰乙酸乙酯衍生物在乙醇中反应，合成了5-取代-4-氧代-1，4-二氢-3-吡啶甲酸乙酯。抗微生物研究所需的1-烷基-5-取代-4-氧代-1，4-二氢-3-吡啶羧酸通过吡啶酮酯的N-烷基化（用磷酸三乙酯或烷基卤化物）和碱性水解制备。
Ethyl 5-substituted-4-oxo-1,4-dihydro-3-pyridinecarboxylates were synthetized by reacting 1,3,5-triazine with 4-substituted ethyl acetoacetate derivatives in ethanol, in the presence of sodium ethoxide. The 1-alkyl-5-substituted-4-oxo-1,4-dihydro-3-pyridinecarboxylic acids required for the antimicrobial studies were prepared by N-alkylation (with triethyl phosphate or alkyl halides) and alkaline hydrolysis of the pyridone esters.