Daily limited access to sweetened drink attenuates hypothalamic-pituitary- adrenocortical axis stress responses
Daily limited access to sweetened drink attenuates hypothalamic-pituitary- adrenocortical axis stress responses
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DOI：
10.1210/en.2006-1241
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发表时间：
2007-04-01
期刊：
影响因子：
4.8
通讯作者：
Herman, James P.
中科院分区：
文献类型：
--
作者：
Ulrich-Lai, Yvonne M.;Ostrander, Michelle M.;Herman, James P.
压力可以促进可口食物的摄入，而可口食物的消费可能会抑制对压力的心理和生理反应。在这里，我们开发了一个大鼠模型，每天有限的甜味饮料摄入量，以进一步研究消费的首选食物和下丘脑-垂体-肾上腺皮质轴的急性和慢性应激反应之间的联系。自由饮水的成年雄性大鼠每天两次额外摄入4 ml蔗糖（30%）、糖精（0.1%;一种无热量甜味剂）或水。经过14天的训练，大鼠很容易学会喝蔗糖和糖精溶液。一半的大鼠，然后给予慢性可变应力（CVS）14天后立即每次饮料曝光;其余的大鼠（nonhandled控制）消耗其适当的饮用水的解决方案在同一时间。在CVS后的早晨，在所有大鼠中评估对新的束缚应激的反应。CVS能有效地改变慢性应激适应的多项指标。蔗糖消耗量降低血浆皮质酮反应的约束压力CVS大鼠和nonhandled控制，这些减少不太明显，在大鼠饮用糖精。蔗糖或糖精消耗减少下丘脑室旁核CRH mRNA的表达。此外，蔗糖衰减抑制诱导的c-fos mRNA表达在基底外侧杏仁核，边缘皮层，屏状核。这些数据表明，有限度的消费加糖饮料减弱下丘脑-垂体-肾上腺皮质轴的应激反应，和热量的贡献，但不是必要的这种效果。总的来说，这些结果支持了这样的假设：美味物质的摄入代表了抑制生理应激反应的内源性机制。
Stress can promote palatable food intake, and consumption of palatable foods may dampen psychological and physiological responses to stress. Here we develop a rat model of daily limited sweetened drink intake to further examine the linkage between consumption of preferred foods and hypothalamic-pituitary-adrenocortical axis responses to acute and chronic stress. Adult male rats with free access to water were given additional twice-daily access to 4 ml sucrose ( 30%), saccharin ( 0.1%; a noncaloric sweetener), or water. After 14 d of training, rats readily learned to drink sucrose and saccharin solutions. Half the rats were then given chronic variable stress ( CVS) for 14 d immediately after each drink exposure; the remaining rats ( nonhandled controls) consumed their appropriate drinking solution at the same time. On the morning after CVS, responses to a novel restraint stress were assessed in all rats. Multiple indices of chronic stress adaptation were effectively altered by CVS. Sucrose consumption decreased the plasma corticosterone response to restraint stress in CVS rats and nonhandled controls; these reductions were less pronounced in rats drinking saccharin. Sucrose or saccharin consumption decreased CRH mRNA expression in the paraventricular nucleus of the hypothalamus. Moreover, sucrose attenuated restraint-induced c-fos mRNA expression in the basolateral amygdala, infralimbic cortex, and claustrum. These data suggest that limited consumption of sweetened drink attenuates hypothalamic-pituitary-adrenocortical axis stress responses, and calories contribute but are not necessary for this effect. Collectively the results support the hypothesis that the intake of palatable substances represents an endogenous mechanism to dampen physiological stress responses.