Analysis of chronic heart failure registry in the Tohoku District - Third year follow-up
Analysis of chronic heart failure registry in the Tohoku District - Third year follow-up
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DOI：
10.1253/circj.68.427
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发表时间：
2004-05-01
影响因子：
3.3
通讯作者：
Shirato, K
中科院分区：
文献类型：
--
作者：
Shiba, N;Watanabe, J;Shirato, K
背景由于日本慢性心力衰竭(CHF)患者的真实预后尚不清楚，本研究的目的是利用东北地区慢性心力衰竭分析和登记(CHF)(图表)来阐明CHF患者的预后和死亡预测因素。方法与结果自2000年2月以来，登记了1154名接受最佳标准治疗的稳定的CHF患者，其中175人在随访期(平均1.9+/-0.9年)内死于某种原因，1年和3年全因死亡率分别为7.3%和20.9%。多因素分析显示，入院年龄、糖尿病、室性心动过速、血浆脑钠素浓度、纽约心脏协会功能分级和农村居住地与全因死亡率显著相关(危险比分别为1.028、1.940、1.650、1.001、1.713和2.226)。左心室射血分数=60 mm、BNP和Gt；=500pg/ml、NYHA和Gt；=III或有基础冠状动脉病变的CHF患者的1年全因死亡率分别为15.0%、11.4%和16.8%。分别为16.3%和10.8%。结论日本心力衰竭患者预后较差。为了提高他们的生存和生活质量，有必要采取分层的方法。
Background Because the real prognosis of Japanese patients with chronic heart failure (CHF) is still unknown, the aim of the present study was to clarify the prognosis and predictors for mortality of CHF patients using the Chronic Heart failure Analysis and Registry in Tohoku district (CHART).Methods and Results As of February 2003, 1,154 stable CHF patients with optimum standard therapy have been enrolled in the registry since February 2000 and of these, 175 died of some cause during the follow-up period (mean follow-up period, 1.9 +/- 0.9 years), giving 1 and 3-year all-cause mortality rates of 7.3% and 20.9%, respectively. Multivariate analysis showed that age at entry, diabetes, ventricular tachycardia, plasma concentration of brain natriuretic peptide (BNP), New York Heart Association (NYHA) functional class and rural residence were significantly associated with all-cause mortality (hazard ratio: 1.028, 1.940, 1.650, 1.001, 1.713, and 2.226). The I-year all-cause mortality rates of CHF patients with a left ventricular ejection fraction = 60mm, BNP >= 500pg/ml, NYHA >= III, or with underlying coronary artery disease were 15.0%, 11.4% 16.8%. 16.3%, and 10.8%, respectively.Conclusions The prognosis of Japanese CHF patients with these predictors remains poor. A stratified approach is necessary to improve their survival and quality of life.