Scaffolds in tissue engineering bone and cartilage
Scaffolds in tissue engineering bone and cartilage
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DOI：
10.1016/s0142-9612(00)00121-6
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发表时间：
2000-12-01
期刊：
影响因子：
14
通讯作者：
Hutmacher, DW
中科院分区：
文献类型：
--
作者：
Hutmacher, DW
肌肉骨骼组织、骨和软骨是组织工程研究中广泛研究的对象。许多可生物降解和可生物吸收的材料，以及支架设计，已经进行了实验和/或临床研究。理想情况下，支架应具有以下特征：(i)三维且高度多孔，具有相互连接的孔网络，用于细胞生长和营养物质和代谢废物的流动运输；（ii）具有生物相容性和生物可吸收性，降解和吸收速率可控，与体外和/或体内细胞/组织生长相匹配；（iii）适合细胞附着、增殖和分化的表面化学性质；（iv）与植入部位的组织相匹配的机械性能。本文从聚合物支架的角度综述了骨软骨组织工程的研究进展。(C) 2000 Elsevier Science Ltd.版权所有。
Musculoskeletal tissue, bone and cartilage are under extensive investigation in tissue engineering research. A number of biodegradable and bioresorbable materials, as well as scaffold designs, have been experimentally and/or clinically studied. Ideally, a scaffold should have the following characteristics: (i) three-dimensional and highly porous with an interconnected pore network for cell growth and flow transport of nutrients and metabolic waste; (ii) biocompatible and bioresorbable with a controllable degradation and resorption rate to match cell/tissue growth in vitro and/or in vivo; (iii) suitable surface chemistry for cell attachment, proliferation, and differentation and (iv) mechanical properties to match those of the tissues at the site of implantation. This paper reviews research on the tissue engineering of bone and cartilage from the polymeric scaffold point of view. (C) 2000 Elsevier Science Ltd. All rights reserved.