Exposure to concentrated ambient air particles alters hematologic indices in humans
Exposure to concentrated ambient air particles alters hematologic indices in humans
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DOI：
10.1080/08958370390249111
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发表时间：
2003-12-01
影响因子：
2.1
通讯作者：
Devlin, RB
中科院分区：
文献类型：
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作者：
Ghio, AJ;Hall, A;Devlin, RB
对血液学指标变化的描述对悬浮颗粒物（PM）的生物效应仅限于肺的前提提出了质疑。采用大约40个反映血细胞、化学物质、介质和凝血因子的血液学参数，我们验证了暴露于高浓度环境空气颗粒（CAPs）可能与正常人血液学指标变化相关的假设。20名健康的年轻志愿者暴露于过滤空气（n = 5）或cap (n = 15)，平均PM质量为120.5 +/- 14.0马克杯/米(3)，范围为15.0 - 357.6马克杯/米(3)。测量血液学指标。所有参数的变化均以曝光后立即或曝光后24小时的绝对值表示。使用独立均值t检验检验过滤空气暴露个体与cap暴露个体的反应差异。如果t检验表明两组之间存在显著差异(p
Descriptions of changes in hematological indices have contested the premise that the biological effects of suspended particulate matter ( PM) are restricted to the lung. Employing approximately 40 hematologic parameters reflecting blood cells, chemistries, mediators, and coagulation factors, we tested the hypothesis that exposure to concentrated ambient air particles (CAPs) can be associated with changes in hematologic indices in normal humans. Twenty healthy young volunteers were exposed to either filtered air (n = 5) or CAPs (n = 15) with a mean PM mass of 120.5 +/- 14.0 mug/m(3) and a range from 15.0 - 357.6 mug/m(3). Hematologic indices were measured. Changes in all parameters are expressed as the absolute value either immediately after or 24 h after exposure. Differences between responses of those individuals exposed to filtered air and CAPs were tested using the T-test of independent means. If significant differences between the two groups were suggested by the T-test ( p