Presence of psychological distress symptoms associated with onset-related life events in patients with treatment-refractory depression
Presence of psychological distress symptoms associated with onset-related life events in patients with treatment-refractory depression
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DOI：
10.1016/j.jad.2015.01.027
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发表时间：
2015-04-01
影响因子：
6.6
通讯作者：
Iyo, Masaomi
中科院分区：
文献类型：
--
作者：
Kimura, Atsushi;Hashimoto, Tasuku;Iyo, Masaomi
背景：以往的研究报道，各种非危及生命的生活事件可能会导致成人和青少年出现创伤后应激障碍等心理痛苦症状。我们调查了难治性抑郁症(TRD)患者是否认为他们的生活事件的经历比缓解或症状轻微的重度抑郁障碍(MOD)患者更严重的心理困扰症状。我们招募了78名门诊患者，其中包括0131名TRD患者，31名缓解的MOD患者和16名症状轻微的MOD患者。我们采用修订的事件影响量表(IES-R)来评估与患者认为引发抑郁发作的事件相关的心理痛苦症状的严重程度。结果：阻塞性睡眠呼吸暂停综合征患者的IES-R平均[+/-SD]分(46.7±15.11)分显著高于缓解组(10.3±19.91)分和轻度症状组(31.3±17.7)分(p<；0.001)。所有患者的HORS评分与IES-R评分呈显著正相关(r=0.811)。局限性：本研究不能排除与发作相关事件相关的心理困扰症状的严重程度影响TRD患者困难治疗过程的可能性。结论：本研究表明，TRD患者将其与发病相关的生活事件视为严重的心理困扰症状。这一结果有助于了解TRD的病理生理学机制。(C)2015爱思唯尔B.V.保留所有权利。
Background: Previous studies have reported that various non-life-threatening life events could cause psychological distress symptoms like posttraumatic stress disorder in adults and adolescents. We examined whether patients with treatment-refractory depression (TRD) perceive their experiences of life events, of which they think as triggering the onset of depression, as more serious psychological distress symptoms than remitted or mildly symptomatic patients with major depressive disorder (MOD).Methods: This study employed a cross-sectional design. We recruited 78 outpatients consisting 0131 TRD patients, 31 remitted MOD patients, and 16 mildly symptomatic MOD patients. We adopted the Impact of Event Scale-Revised (IES-R) to assess the severity of psychological distress symptoms associated with the events that patients thought as triggering the onset of depression. We also evaluated clinical features and variables including the Hamilton Depression Rating Scale (HORS).Results: The mean [+/- SD] score of the IES-R in patients with TRD (46.7 [15.11) was significantly higher than in remitted (10.3 19.91, p < 0.001) or mildly symptomatic (31.3 [17.7], p < 0.001) patients with MOD. The HORS scores showed significant correlations with those of the IES-R among all patients (r=0.811). Limitations: This study was not able to exclude the possibility that the severity of psychological distress symptoms associated with onset-related events could influence the difficult therapeutic course in patients with TRD clue to the cross-sectional design.Conclusions: This study demonstrated that patients with TRD perceive their onset-related life events as serious psychological distress symptoms. This result contributes to understanding the pathophysiology of TRD. (C) 2015 Elsevier B.V. All rights reserved.