17beta-estradiol protects male mice from cuprizone-induced demyelination and oligodendrocyte loss.
17beta-estradiol protects male mice from cuprizone-induced demyelination and oligodendrocyte loss.
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DOI：
10.1016/j.nbd.2010.03.016
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发表时间：
2010-08
影响因子：
6.1
通讯作者：
Matsushima GK
中科院分区：
文献类型：
--
作者：
Taylor LC;Puranam K;Gilmore W;Ting JP;Matsushima GK
除了调节脑和外周的生殖功能外，雌激素在中枢神经系统（CNS）中具有营养和神经保护功能。雌激素给药已被证明在几种CNS疾病的动物模型中提供保护，包括中风、脑损伤、癫痫、帕金森病、阿尔茨海默病、年龄相关的认知下降和多发性硬化。在这里，我们使用毒素诱导的少突胶质细胞死亡模型，导致脱髓鞘，反应性胶质增生，少突胶质细胞前体细胞的募集和随后的髓鞘再生，以研究17β-雌二醇（E2）给药在雄性小鼠中的潜在益处。结果表明，E2部分改善胼胝体中少突胶质细胞的丢失和脱髓鞘。这种保护作用伴随着小胶质细胞蓄积延迟以及促炎细胞因子、肿瘤坏死因子α（TNFα）和胰岛素样生长因子-1（IGF-1）mRNA表达减少。E2没有显着改变星形胶质细胞或少突胶质细胞前体细胞的积累，或髓鞘再生。这些数据从一个毒素诱导的，T细胞非依赖性模型，使用雄性小鼠提供了一个扩大的观点，雌激素对少突胶质细胞和髓鞘保存的有益影响。
In addition to regulating reproductive functions in the brain and periphery, estrogen has trophic and neuroprotective functions in the central nervous system (CNS). Estrogen administration has been demonstrated to provide protection in several animal models of CNS disorders, including stroke, brain injury, epilepsy, Parkinson’s disease, Alzheimer’s disease, age-related cognitive decline and multiple sclerosis. Here, we use a model of toxin-induced oligodendrocyte death which results in demyelination, reactive gliosis, recruitment of oligodendrocyte precursor cells and subsequent remyelination to study the potential benefit of 17β-estradiol (E2) administration in male mice. The results indicate that E2 partially ameliorates loss of oligodendrocytes and demyelination in the corpus callosum. This protection is accompanied by a delay in microglia accumulation as well as reduced mRNA expression of the pro-inflammatory cytokine, tumor necrosis factor alpha (TNFα), and insulin-like growth factor-1 (IGF-1). E2 did not significantly alter the accumulation of astrocytes or oligodendrocyte precursor cells, or remyelination. These data obtained from a toxin-induced, T cell-independent model using male mice provide an expanded view of the beneficial effects of estrogen on oligodendrocyte and myelin preservation.
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DOI：
10.1016/0960-0760(92)90394-x
发表时间：
1992-03-01
影响因子：
4.1
作者：
JUNGTESTAS, I;RENOIR, M;BAULIEU, EE
通讯作者：
BAULIEU, EE
影响因子：
10.4
作者：
Durrer S;Ehnes C;Fuetsch M;Maerkel K;Schlumpf M;Lichtensteiger W
通讯作者：
Lichtensteiger W
影响因子：
3.3
作者：
Drew, PD;Chavis, JA
通讯作者：
Chavis, JA
影响因子：
4.8
作者：
Bruce-Keller, AJ;Keeling, JL;Mattson, MP
通讯作者：
Mattson, MP
影响因子：
3.3
作者：
Iocca, Heather A.;Plant, Sheila R.;Ting, Jenny P-Y.
通讯作者：
Ting, Jenny P-Y.