Population dynamics of a pathogen: the conundrum of vivax malaria.
Population dynamics of a pathogen: the conundrum of vivax malaria.
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DOI：
10.1007/s12551-010-0034-3
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发表时间：
2010-08
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建立宿主内病原体种群动态的数学模型涉及到与生态学中的因素类似的因素，因为病原体可以捕食宿主中的细胞。但在多细胞宿主中，受攻击的细胞类型与其他细胞系统整合，从而干预感染。例如，免疫反应试图感知并消除或遏制病原体，稳态机制试图补偿细胞损失。这篇评论的重点是应用于疟疾的建模，疟疾是由感染红细胞的单细胞真核生物寄生虫引起的疾病，特别关注间日疟，这种疾病通常被认为是良性的（如果有时使人丧失能力），因为寄生虫只攻击一小部分红细胞，非常年轻的红细胞。然而，我将使用数学模型来论证，如果寄生虫的生长没有受到宿主免疫反应的有力抑制，那么红细胞池的耗尽可能对宿主造成灾难性的后果。此外，模型可以阐明新的实地观察的方面，表明间日疟比以前认为的更危险。本文的在线版本（doi：10.1007/s12551-010-0034-3）包含补充材料，可供授权用户使用。
Building a mathematical model of population dynamics of pathogens within their host involves considerations of factors similar to those in ecology, as pathogens can prey on cells in the host. But within the multicellular host, attacked cell types are integrated with other cellular systems, which in turn intervene in the infection. For example, immune responses attempt to sense and then eliminate or contain pathogens, and homeostatic mechanisms try to compensate for cell loss. This review focuses on modeling applied to malarias, diseases caused by single-cell eukaryote parasites that infect red blood cells, with special concern given to vivax malaria, a disease often thought to be benign (if sometimes incapacitating) because the parasite only attacks a small proportion of red blood cells, the very youngest ones. However, I will use mathematical modeling to argue that depletion of this pool of red blood cells can be disastrous to the host if growth of the parasite is not vigorously check by host immune responses. Also, modeling can elucidate aspects of new field observations that indicate that vivax malaria is more dangerous than previously thought. The online version of this article (doi:10.1007/s12551-010-0034-3) contains supplementary material, which is available to authorized users.