Plasma concentrations of fibroblast growth factors 19 and 21 in patients with anorexia nervosa
Plasma concentrations of fibroblast growth factors 19 and 21 in patients with anorexia nervosa
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DOI：
10.1210/jc.2008-0746
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发表时间：
2008-09-01
影响因子：
5.8
通讯作者：
Haluzik, Martin
中科院分区：
文献类型：
--
作者：
Dostalova, Ivana;Kavalkova, Petra;Haluzik, Martin
背景：成纤维细胞生长因子19(FGF19)和成纤维细胞生长因子21(FGF21)是新的代谢调节剂，可改善小鼠的胰岛素敏感性和降低肥胖。目的：测定神经性厌食症(AN)患者血浆FGF19和FGF21水平，并探讨其与人体测量学和内分泌参数的关系。设计：单中心横断面研究。地点：在一所大学医院进行。研究对象：17例未经治疗的限制性神经性厌食症患者和17例健康女性(对照组)。主要观察指标：空腹血浆FGF19和FGF21、血清胰岛素、瘦素、可溶性瘦素受体、脂联素、抵抗素、结果：与对照组相比，两组间血浆FGF19水平无显著差异，而血浆FGF21水平显著降低。两组患者血浆FGF21与体重指数、血清瘦素、胰岛素呈正相关，与血清脂联素呈负相关。相反，血浆FGF19与所研究的任何参数均无相关性。部分厌食症患者血浆FGF21水平显著降低。结论：厌食症和正常体重妇女循环中FGF21水平与体重及血清瘦素、脂联素和胰岛素水平密切相关，而与FGF19水平无关。我们认为血浆FGF21水平降低可能参与AN的病理生理学或对该疾病的复杂适应性反应。
Context: Fibroblast growth factor 19 (FGF19) and FGF21 are novel metabolic regulators that improve insulin sensitivity and decrease adiposity in mice. However, little is known about the nutritional regulation of these factors in humans.Objective: The objective of this study was to measure plasma FGF19 and FGF21 levels in patients with anorexia nervosa (AN) and to explore its relationship with anthropometric and endocrine parameters.Design: This was a single-center cross-sectional study.Setting: The study was performed in a university hospital.Patients: Seventeen untreated women with a restrictive type of AN and 17 healthy women (control group) were included.Main Outcome Measures: Fasting plasma FGF19 and FGF21, serum insulin, leptin, soluble leptin receptor, adiponectin, resistin, and C-reactive protein were the main outcome measures.Results: Plasma FGF19 levels did not significantly differ between the groups studied, whereas plasma FGF21 levels were significantly reduced in AN relative to the control group. Plasma FGF21 positively correlated with body mass index and serum leptin and insulin and was inversely related to serum adiponectin in both groups. In contrast, plasma FGF19 was not related to any of parameters studied. Partial realimentation significantly reduced plasma FGF21 levels in AN.Conclusion: Circulating levels of FGF21 but not FGF19 are strongly related to body weight and serum levels of leptin, adiponectin, and insulin in both anorectic and normal-weight women. We suggest that reduced plasma FGF21 levels could be involved in the pathophysiology of AN or in a complex adaptive response to this disease.