Melanocyte-specific CD49a+CD8+ T cells in vitiligo lesion potentiate to maintain activity during systemic steroid therapy.
Melanocyte-specific CD49a+CD8+ T cells in vitiligo lesion potentiate to maintain activity during systemic steroid therapy.
复制标题
白癜风病变中黑素细胞特异性 CD49a CD8 T 细胞在全身类固醇治疗期间增强维持活性。
DOI：
10.1111/1346-8138.16680
复制
发表时间：
2023
影响因子：
3.1
通讯作者：
Tanemura A
中科院分区：
文献类型：
--
作者：
Yokoi K;Watanabe R;Kume M;Yamane S;Tanaka A;Fujimoto M;Tanemura A
白癜风是一种常见的色素脱失性皮肤病，往往很难治疗。即使通过治疗实现了色素恢复，在停止治疗后的一年内，同一病变经常会复发。作为这些问题的背景，一个识别黑素细胞特异性抗原的CD 8 +T细胞亚群或存在于白癜风病变中的CD 49 a+组织驻留记忆T细胞被认为参与其中。我们研究了一名HLA-A *02：01的进行性泛发性白癜风患者的MHC I类限制性酪氨酸酶五聚体阳性CD 8+皮肤T细胞，该患者对静脉内甲泼尼龙冲击治疗表现出耐药性。我们发现，治疗后，HLA-A *02：01限制性酪氨酸酶五聚体阳性CD 8 +T细胞仍保留在病变中，并表达IFN-γ和颗粒酶B。有趣的是，静脉内甲基强的松龙冲击治疗后，五聚体阴性CD 8 +T细胞中这些细胞因子的表达降低。这些发现表明，在白癜风患者中，黑素细胞特异性CD 49 a + CD 8 +T细胞处于有效的活化状态，尽管进行了全身免疫抑制治疗，但这种活化状态仍不受控制，这可能导致治疗抵抗和局部复发。
Vitiligo is a common depigmenting skin disease that is often difficult to treat. Even if repigmentation is achieved by treatment, recurrence in the same lesion is often found within a year after stopping treatment. As a background of these issues, a subset of CD8+T cells that recognize melanocyte‐specific antigens or CD49a+tissue‐resident memory T cells that reside in the vitiligo lesion are thought to be involved. We investigated the MHC class I‐restricted tyrosinase pentamer‐positive CD8+skin T cells in a progressive generalized vitiligo patient with HLA‐A*02:01 who showed resistance to intravenous methylprednisolone pulse therapy. We found that HLA‐A*02:01‐restricted tyrosinase pentamer‐positive CD8+T cells remained in the lesions after the treatment and expressed IFN‐γ and granzyme B. Interestingly, the expression of these cytokines in the pentamer‐negative CD8+T cells was decreased after intravenous methylprednisolone pulse therapy. These findings suggest that, in vitiligo patients, melanocyte‐specific CD49a+CD8+T cells are in a potent activation state that is uncontrolled despite systemic immunosuppressive treatment, which may contribute to treatment resistance and local recurrence.