Combined effect of tobacco and alcohol on laryngeal cancer risk: a case-control study
Combined effect of tobacco and alcohol on laryngeal cancer risk: a case-control study
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DOI：
10.1023/a:1021944123914
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发表时间：
2002-12-01
影响因子：
2.3
通讯作者：
Franceschi, S
中科院分区：
文献类型：
--
作者：
Talamini, R;Bosetti, C;Franceschi, S
目的：探讨烟酒对喉癌及其亚位点的影响。方法：这是一项1992年至2000年间在意大利北部和瑞士进行的病例对照研究。共纳入527例喉部鳞状细胞癌偶发病例和1297例与年龄、性别和居住地区病例频率匹配的医院对照。比值比（ORs）和相应的95%置信区间（ci）采用多元逻辑回归估计。结果：与从不吸烟者相比，当前吸烟者的or为19.8，戒烟者的or为7.0。与吸烟数量（大于或等于25支/天）和吸烟时间（大于或等于40年）相关的风险增加（OR = 42.9）。对于酒精，风险增加与饮酒次数有关（OR = 5.9，大于或等于每周饮酒56次）。酒精和烟草混合消费显示了乘数风险（OR = 177），而不是加性风险。对于当前吸烟者和当前饮酒者，声门上炎的风险（分别为54.9和2.6）高于声门炎（分别为7.4和1.8）和其他子部位（分别为10.9和1.9）。结论：我们的研究表明吸烟和饮酒都是喉癌的独立危险因素。大量饮酒和吸烟导致了成倍的风险增加，这可能表明生物协同作用。
Objective: To provide information on the effects of alcohol and tobacco on laryngeal cancer and its subsites.Methods: This was a case-control study conducted between 1992 and 2000 in northern Italy and Switzerland. A total of 527 cases of incident squamous-cell carcinoma of the larynx and 1297 hospital controls frequency-matched with cases on age, sex, and area of residence were included. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using multiple logistic regression.Results: In comparison with never smokers, ORs were 19.8 for current smokers and 7.0 for ex-smokers. The risk increased in relation to the number of cigarettes (OR = 42.9 for greater than or equal to25 cigarettes/day) and for duration of smoking (OR = 37.2 for greater than or equal to40 years). For alcohol, the risk increased in relation to number of drinks (OR = 5.9 for greater than or equal to56 drinks per week). Combined alcohol and tobacco consumption showed a multiplicative (OR = 177) rather than an additive risk. For current smokers and current drinkers the risk was higher for supraglottis (ORs 54.9 and 2.6, respectively) than for glottis (ORs 7.4 and 1.8) and others subsites (ORs 10.9 and 1.9).Conclusions: Our study shows that both cigarette smoking and alcohol drinking are independent risk factors for laryngeal cancer. Heavy consumption of alcohol and cigarettes determined a multiplicative risk increase, possibly suggesting biological synergy.