Statistical analyses in trials for the comprehensive understanding of organogenesis and histogenesis in humans and mice
Statistical analyses in trials for the comprehensive understanding of organogenesis and histogenesis in humans and mice
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全面了解人类和小鼠器官发生和组织发生的试验统计分析
DOI：
10.1093/jb/mvw020
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发表时间：
2016
影响因子：
2.7
通讯作者：
Jun Udagawa and Kanta Naito
中科院分区：
文献类型：
--
作者：
Hiroki Otani;Jun Udagawa and Kanta Naito
除了使用数学模型的演绎分析外，基于真实多细胞生物体的定量数据的统计分析对于分析复杂的形态发生事件也是有用的归纳型研究。在这里，我们介绍了我们对人类和小鼠胚胎和胎儿器官发生和组织发生的统计分析的几个试验。多维标尺已被应用于证明和研究运动间核迁移的方式，这是上皮肾小管组织中干细胞增殖/分化的一种调节机制。用多种统计方法对胎儿的形态测量数据进行了分析，建立了多维标准生长曲线，描述了各发育器官与各部位之间的关系。尽管结果仍然有限，但我们表明，这些分析不仅有助于了解人类和小鼠的正常和异常形态发生，而且还提供了可能将产前发育事件的某些方面与出生后疾病相关联的线索。
Statistical analyses based on the quantitative data from real multicellular organisms are useful as inductive-type studies to analyse complex morphogenetic events in addition to deductive-type analyses using mathematical models. Here, we introduce several of our trials for the statistical analysis of organogenesis and histogenesis of human and mouse embryos and foetuses. Multidimensional scaling has been applied to prove the existence and examine the mode of interkinetic nuclear migration, a regulatory mechanism of stem cell proliferation/differentiation in epithelial tubular tissues. Several statistical methods were used on morphometric data from human foetuses to establish the multidimensional standard growth curve and to describe the relation among the developing organs and body parts. Although the results are still limited, we show that these analyses are not only useful to understand the normal and abnormal morphogenesis in humans and mice but also to provide clues that could correlate aspects of prenatal developmental events with postnatal diseases.