Prenatal Exposures to Perfluorinated Chemicals and Anthropometric Measures in Infancy
Prenatal Exposures to Perfluorinated Chemicals and Anthropometric Measures in Infancy
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DOI：
10.1093/aje/kwq289
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发表时间：
2010-12-11
影响因子：
5
通讯作者：
Olsen, Jorn
中科院分区：
文献类型：
--
作者：
Andersen, Camilla Schou;Fei, Chunyuan;Olsen, Jorn
全氟辛烷磺酸（PFOS）和全氟辛酸（PFOA）是持久性化学品，可能会影响生命早期的生长。作者估计了母亲血浆中的全氟辛烷磺酸和全氟辛酸水平与婴儿出生后第一年的体重、身长和体重指数之间的关系。1996年至2002年，从丹麦国家出生队列中随机选择了1400名妇女，这些妇女在怀孕早期提供了血液样本，并在1996年至2002年期间生下了活产单胎。可获得1，010名儿童5个月和12个月时的体重和身长信息。采用多元线性回归模型进行分析，母体全氟辛烷磺酸和全氟辛酸浓度（纳克/毫升）与儿童出生后第一年的体重呈负相关：调整后的回归系数：-1.1克（95%置信区间（CI）：-4.6，2.3），5个月和-5.8 g全氟辛烷磺酸在12个月时为-10.4克（95%可信区间：-1.2）;全氟辛酸在5个月时为-10.6克（95%可信区间：-30.2，8.9），12个月时为-19.7克（95%可信区间：-45.9，6.5）。体重指数的测量结果也有类似的模式，与身高没有相关性。性别分层后，体重和体重指数的负相关性在男孩中更为明显，在女孩中没有明显的相关性。
Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) are persistent chemicals that may affect growth early in life. The authors estimated the associations between maternal plasma levels of PFOS and PFOA and infants' weight, length, and body mass index development during the first year of life. Fourteen hundred women were randomly selected from the Danish National Birth Cohort among those who provided blood samples early in pregnancy and gave birth to liveborn singletons between 1996 and 2002. Weight and length information at 5 and 12 months of age was available for 1,010 children. Multiple linear regression models were used for analyses, and maternal PFOS and PFOA concentrations (ng/mL) were inversely related to children's weight in the first year of life: adjusted regression coefficients: -1.1 g (95% confidence interval (CI): -4.6, 2.3) at 5 months and -5.8 g (95% CI: -10.4, -1.2) at 12 months for PFOS; -10.6 g (95% CI: -30.2, 8.9) at 5 months and -19.7 g (95% CI: -45.9, 6.5) at 12 months for PFOA. A similar pattern was observed for body mass index measurements, and no associations with length were found. After sex stratification, the inverse associations with weight and body mass index were more pronounced in boys, and no clear association was seen for girls.