Effect of cardiogenic and noncardiogenic pulmonary edema on histamine responsiveness in sheep.
Effect of cardiogenic and noncardiogenic pulmonary edema on histamine responsiveness in sheep.
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心源性和非心源性肺水肿对绵羊组胺反应性的影响。
DOI：
10.1152/jappl.1998.85.5.1635
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Plitman,JD
中科院分区：
文献类型：
--
作者：
Snapper,JR;Lefferts,PL;Lu,W;Hwang,YS;Plitman,JD
我们比较了心源性肺水肿、无明显水肿的短暂肺血管充血和非心源性肺水肿对长期监测的清醒羊对吸入组胺反应的影响。测量前后的组胺反应性：1) 通过部分阻塞二尖瓣血流将左心房压力升高至 35 cmH2O (↑Pla) 3.5 小时诱发心源性肺水肿，2) 通过 ↑Pla 短暂心源性充血 0.5 小时，3) 25 mg/kg 静脉注射紫苏酮 (PK) 诱发非心源性肺水肿，以及 4) 3.5 小时无 ↑Pla 监测或 PK（对照）。使用 ↑Pla (n= 9) 和 PK (n= 11) 治疗 3.5 小时，均显着减少了导致基线动态肺顺应性 (ED65Cdyn) 下降至 65% 所需的组胺剂量，即反应性增加。用 ↑Pla 处理 0.5 小时的绵羊 (n= 7) 和对照组 (n= 5) 的 ED65Cdyn 没有显着变化。在第二次组胺攻击前静脉注射阿托品 (0.1 mg/kg) 既不改变 ↑Pla (n= 8) 和 PK (n= 9) 羊中 ED65Cdyn 的降低，也不改变对照羊 (n= 9) 的 ED65Cdyn 水平。这些数据表明，在绵羊肺水肿过程中，与肺高反应性密切相关的是水肿的局部影响，而不是支气管血管血流动力学、胆碱能反射和通透性变化。
We compared the effects of cardiogenic pulmonary edema, brief pulmonary vascular congestion without frank edema, and noncardiogenic pulmonary edema on responsiveness to inhaled histamine in chronically instrumented awake sheep. Histamine responsiveness was measured before and after1) cardiogenic pulmonary edema induced by raising left atrial pressure to 35 cmH2O (↑Pla) for 3.5 h by partial obstruction of flow across the mitral valve,2) brief cardiogenic congestion via ↑Pla for 0.5 h,3) noncardiogenic pulmonary edema induced by 25 mg/kg intravenous perilla ketone (PK), and4) 3.5 h of monitoring without ↑Pla or PK (controls). Treatment for 3.5 h with ↑Pla (n= 9) and PK (n= 11) each significantly lessened the histamine dose required to cause a fall to 65% of baseline dynamic lung compliance (ED65Cdyn), i.e., increased responsiveness. Sheep treated for 0.5 h with ↑Pla (n= 7) and controls (n= 5) showed no significant change in ED65Cdyn. Intravenous atropine (0.1 mg/kg) before the second histamine challenge altered neither the reduction of ED65Cdyn in ↑Pla (n= 8) and PK (n= 9) sheep nor the ED65Cdyn level of controls (n= 9). These data imply that the local effects of edema, rather than bronchial vascular hemodynamics, cholinergic reflexes, and permeability changes, are germane to lung hyperresponsiveness during pulmonary edema in sheep.