RELATIONSHIP OF SEX HORMONE-BINDING GLOBULIN TO LIPID, LIPOPROTEIN, GLUCOSE, AND INSULIN CONCENTRATIONS IN POSTMENOPAUSAL WOMEN
RELATIONSHIP OF SEX HORMONE-BINDING GLOBULIN TO LIPID, LIPOPROTEIN, GLUCOSE, AND INSULIN CONCENTRATIONS IN POSTMENOPAUSAL WOMEN
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DOI：
10.1016/0026-0495(92)90271-b
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发表时间：
1992-03-01
影响因子：
9.8
通讯作者：
KATZ, MS
中科院分区：
文献类型：
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作者：
HAFFNER, SM;DUNN, JF;KATZ, MS
性激素在决定心血管疾病的风险方面起着重要作用。虽然一些研究表明，减少性激素结合球蛋白（SHBG）与增加胰岛素和甘油三酯和降低高密度脂蛋白胆固醇（HDLC）在绝经前妇女，绝经后妇女的数据很少。我们假设绝经后妇女SHBG降低与心血管危险因素的致动脉粥样硬化模式有关。我们测量了101名绝经后妇女的SHBG、血脂、脂蛋白、葡萄糖和胰岛素浓度，以及收缩压和舒张压。SHBG与甘油三酯（r=-0.21）和胰岛素（r=-0.47）浓度呈负相关，与HDL C浓度呈正相关（r= 0.47）。在校正了总体肥胖（体重指数）和上身肥胖（通过腰围与臀围的比值测量）后，SHBG仍然与HDL C和胰岛素相关，但与甘油三酯无关。性激素与收缩压和舒张压无关。结果可能有助于解释增加雄激素的关联，如较低的SHBG浓度，与糖尿病和老年妇女心血管疾病的风险。
Sex hormones play a major role in determining the risk of cardiovascular disease. While several studies have shown that reduced sex hormone-binding globulin (SHBG) is associated with increased insulin and triglyceride and decreased high-density lipoprotein cholesterol (HDLC) in premenopausal women, little data are available for postmenopausal women. We hypothesized that in postmenopausal women decreased SHBG would be associated with an atherogenic pattern of cardiovascular risk factors. We measured SHBG, lipids, lipoproteins, glucose, and insulin concentrations, and systolic and diastolic blood pressure in 101 postmenopausal women. SHBG was negatively associated with triglyceride (r= −.21) and insulin (r= −.47) concentrations and positively associated with HDLC concentrations (r= .47). After adjustment for overall adiposity (body mass index) and upper body adiposity (as measured by the ratio of waist to hip circumferences), SHBG was still associated with HDLC and insulin, but not with triglyceride. Sex hormones were not related to systolic and diastolic blood pressure. The results may help to explain an association of increased androgenicity, as measured by a lower SHBG concentration, with diabetes and risk of cardiovascular disease in older women.