Impact of MCP-1 in Atherosclerosis
Impact of MCP-1 in Atherosclerosis
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DOI：
10.2174/1381612820666140522115801
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发表时间：
2014-01-01
影响因子：
3.1
通讯作者：
Lu, Xinjie
中科院分区：
文献类型：
--
作者：
Lin, Juntang;Kakkar, Vijay;Lu, Xinjie
单核细胞趋化蛋白-1（MCP-1）（也称为趋化因子（C-C基序）配体2（CCL2）主要由炎症细胞和内皮细胞表达。在与动脉粥样硬化病变相关的促炎刺激和组织损伤后，表达水平上调。动脉粥样硬化是一种进行性疾病，始于动脉壁中脂质、脂蛋白和免疫细胞的积累。据报道，MCP-1 在动脉粥样硬化的发病机制中发挥着重要作用，并且大量证据支持含有 MCP 的单核细胞和巨噬细胞影响动脉粥样硬化病变内其他细胞类型的生长。本综述将重点介绍 MCP-1 的一般结构特征及其在动脉粥样硬化中的作用。
Monocyte chemotactic protein-1 (MCP-1) (also referred to as chemokine (C-C motif) ligand 2 (CCL2) is expressed by mainly inflammatory cells and endothelial cells. The expression level is upregulated after proinflammatory stimuli and tissue injury which are associated with atherosclerotic lesion. Atherosclerosis is a progressive disease starting with accumulation of lipids, lipoproteins, and immune cells in the arterial wall. MCP-1 has been reported to play an important role in the pathogenesis of atherosclerosis and considerable evidence supports that the monocyte containing MCPs and macrophage influences the growth of other cell types within the atherosclerotic lesion. This review will focus on the general structure features of MCP-1 and its role in atherosclerosis.