DIFFERENTIAL CONTROL OF SYMPATHETIC ACTIVITY TO KIDNEY AND SKELETAL-MUSCLE BY VENTRAL MEDULLARY NEURONS
DIFFERENTIAL CONTROL OF SYMPATHETIC ACTIVITY TO KIDNEY AND SKELETAL-MUSCLE BY VENTRAL MEDULLARY NEURONS
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DOI：
10.1016/0165-1838(92)90139-8
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发表时间：
1992-01-01
期刊：
影响因子：
--
通讯作者：
KAMPINE, JP
中科院分区：
文献类型：
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作者：
DEAN, C;SEAGARD, JL;KAMPINE, JP
将D，L-同型半胱氨酸微量注射到猫延髓腹外侧的局部区域，可引起动脉血压升高。在升压反应中，可识别出三种交感神经放电模式。从面神经核的腹内侧到尾极的部位可以引出由肾神经活动增加和对骨骼肌血管系统的交感神经活动无变化组成的差异模式。从更外侧和尾部的网站，一个广义的交感神经兴奋诱发流出到肾脏和后肢肌肉血管。第三个反应，肌肉交感神经活动的差异性增加，同时在肾神经活动的小幅度减少，可以诱发从尾部网站，外侧的下橄榄和浅表的腹面。结果表明，腹侧延髓神经元可以选择性地激活交感神经流出，以控制特定的血管床。这些数据可能支持的假设，腹外侧髓质包含离散组的拓扑结构排列的神经元，可以差异控制交感神经紧张的各种终末器官。
A rise in arterial blood pressure can be evoked by microinjections Of D,L-homocysteic acid into localized regions of the ventrolateral medulla of the cat. Three patterns of sympathetic discharge can be identified during the pressor response. A differential pattern consisting of an increase in renal nerve activity and no change in sympathetic activity to skeletal muscle vasculature can be elicited from sites ventromedial to the caudal pole of the facial nucleus. From more lateral and caudal sites, a generalized sympatho-excitation is evoked in the outflow to both the kidney and hindlimb muscle vasculature. A third response consisting of a differential increase in muscle sympathetic activity simultaneous with a small decrease in renal nerve activity could be evoked from caudal sites, lateral to the inferior olives and superficial to the ventral surface. The results show that ventral medullary neurons can selectively activate sympathetic outflow to control specific vascular beds. These data may support the hypothesis that the ventrolateral medulla contains discrete groups of topographically arranged neurons that can differentially control sympathetic tone to various end-organs.