Boron-Doped Nanocrystalline Diamond Electrodes for Neural Interfaces: In vivo Biocompatibility Evaluation.
Boron-Doped Nanocrystalline Diamond Electrodes for Neural Interfaces: In vivo Biocompatibility Evaluation.
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DOI：
10.3389/fnins.2016.00087
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发表时间：
2016
影响因子：
4.3
通讯作者：
Pennisi CP
中科院分区：
文献类型：
--
作者：
Alcaide M;Taylor A;Fjorback M;Zachar V;Pennisi CP
硼掺杂纳米金刚石（BDD）电极由于其上级的物理和电化学性能而作为神经电极材料最近引起了人们的注意，然而其生物相容性在很大程度上尚未被探索。在这项工作中，我们的目的是研究在体内生物相容性的BDD电极与传统的氮化钛（TiN）电极使用大鼠皮下植入模型。高品质的BDD膜合成电极预期用作植入式神经刺激装置。植入2周和4周后，获得电极附近的组织切片用于组织学分析。两种类型的植入物都包含在薄的纤维封装层中，其厚度随时间而减小。尽管植入物周围的新血管形成水平相似，但BDD电极在两个时间点引起了显著更薄的纤维囊和更轻微的炎症反应。这些结果表明，BDD膜可以构成适当的材料，以支持植入式神经电极随时间的稳定性能。
Boron-doped nanocrystalline diamond (BDD) electrodes have recently attracted attention as materials for neural electrodes due to their superior physical and electrochemical properties, however their biocompatibility remains largely unexplored. In this work, we aim to investigate the in vivo biocompatibility of BDD electrodes in relation to conventional titanium nitride (TiN) electrodes using a rat subcutaneous implantation model. High quality BDD films were synthesized on electrodes intended for use as an implantable neurostimulation device. After implantation for 2 and 4 weeks, tissue sections adjacent to the electrodes were obtained for histological analysis. Both types of implants were contained in a thin fibrous encapsulation layer, the thickness of which decreased with time. Although the level of neovascularization around the implants was similar, BDD electrodes elicited significantly thinner fibrous capsules and a milder inflammatory reaction at both time points. These results suggest that BDD films may constitute an appropriate material to support stable performance of implantable neural electrodes over time.