Foot shock stress prolongs the telogen stage of the spontaneous hair cycle in a non-depilated mouse model
Foot shock stress prolongs the telogen stage of the spontaneous hair cycle in a non-depilated mouse model
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DOI：
10.1111/j.1600-0625.2007.00558.x
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发表时间：
2007-07-01
影响因子：
3.6
通讯作者：
Kawana, Seiji
中科院分区：
文献类型：
--
作者：
Katayama, Mirei;Aoki, Eri;Kawana, Seiji
背景：越来越多的证据表明，应激可影响皮肤疾病和皮肤功能。以前的研究表明，压力会改变小鼠的毛发周期;然而，这些研究是通过使用小鼠模型进行的，其中毛发周期在脱毛后被强制同步。目的：为了检测足部电击应力（FS）是否改变非脱毛动物模型中的自发毛发周期，探讨肥大细胞和P物质（SP）在应激对毛发周期影响中的作用。在非脱毛小鼠中，观察了FS 3-4周期间自发毛发周期的变化和特异性SP NK 1受体拮抗剂的抑制作用。在动物模型中，足部电击应激延长了毛发周期的休止期阶段，并延迟了随后的毛发生长期阶段的诱导。FS引起皮肤中脱颗粒肥大细胞的比例增加，TUNEL阳性细胞的数量增加，Ki 67阳性细胞的数量减少。NK 1受体拮抗剂，WIN 62577，抑制这些应力responses.Conclusions：我们的研究结果强烈支持以前的工作，表明应力改变活跃的毛发周期在体内通过SP的作用。
Background: There is an increasing evidence to indicate that stress can influence skin disease and cutaneous functions. Previous studies have shown that stress alters the murine hair cycle; however, these studies have been carried out by using mouse models in which the hair cycle is forcibly synchronized after depilation.Objective: To examine whether foot shock stress (FS) changes the spontaneous hair cycle in a non-depilated animal model, and to evaluate the role of mast cells and substance P (SP) in the influence of stress on the hair cycle.Methods: Changes in the spontaneous hair cycle and the inhibitory effects of a specific SP NK1 receptor antagonist were examined in non-depilated mice during 3-4 weeks of FS.Resutls: Foot shock stress prolonged the telogen stage of the hair cycle and delayed the induction of the subsequent anagen stage in the animal model. FS caused an increase in the ratio of de-granulated mast cells in the skin, an increase in the number of TUNEL-positive cells, and a decrease in the number of Ki67-positive cells. The NK1 receptor antagonist, WIN 62577, inhibited these stress responses.Conclusions: Our results strongly support previous work, demonstrating that stress alters active hair-cycling in vivo through the action of SP.