Risk for the development of non-alcoholic fatty liver disease: A prospective study
Risk for the development of non-alcoholic fatty liver disease: A prospective study
复制标题
发生非酒精性脂肪肝的风险：一项前瞻性研究
DOI：
10.1111/jgh.14105
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发表时间：
2018-08-01
影响因子：
4.1
通讯作者：
Xu, Chengfu
中科院分区：
文献类型：
--
作者：
Wang, Jinghua;Ma, Liang;Xu, Chengfu
背景与目的无创评估被广泛用于在代谢风险增加的个体中识别非酒精性脂肪性肝病(NAFLD)的风险。本研究旨在探讨ZJU指数与非酒精性脂肪肝(NAFLD)发病的关系。应用腹部超声诊断NAFLD。计算具有不同基线ZJU指数五分位数的参与者的NAFLD发病率。采用COX比例风险回归分析计算非酒精性脂肪肝发病的危险性。结果在37705人年的随访中，确诊了1071例非酒精性脂肪肝病例。基线ZJU指数与NAFLD发病率呈线性正相关。在基线ZJU指数为1-5的参与者中，每1000人年随访的发病率分别为5.53、11.75、23.77、43.28和85.60例。与基线ZJU指数为1的参与者相比，基线ZJU指数为2-5的参与者发生非酒精性脂肪肝的风险比(95%可信区间)分别为2.092(1.458-3.002)、4.094(2.942-5.698)、7.095(5.167-9.742)和13.191(9.684-17.968)。进一步分析发现，随访期间ZJU指数的变化也与NAFLD发生的风险独立相关。结论基线ZJU指数和ZJU指数的绝对变化独立预测中国人群发生NAFLD的风险。
Background and AimNon-invasive assessment was widely used to identify the risk of non-alcoholic fatty liver disease (NAFLD) among individuals with increased metabolic risks. This study aimed to investigate the prospective relationship between ZJU index and the development of NAFLD in a Chinese population.MethodsA cohort of 6310 initially NAFLD-free participants was enrolled in this prospective study. Abdominal ultrasound was used to diagnosis NAFLD. NAFLD incidence was calculated among participants with different baseline ZJU index quintiles. Cox proportional hazards regression analyses were conducted to calculate the risks for incident NAFLD.ResultsDuring 37705 person-year follow-ups, 1071 incident NAFLD cases were identified. The baseline ZJU index was linear and positively correlated with NAFLD incidence. The incidence was 5.53, 11.75, 23.77, 43.28, and 85.60 cases per 1000 person-year follow-up for participants with baseline ZJU index in quintiles 1-5, respectively. Compared with participants with baseline ZJU index in quintile 1, the hazard ratios (95% confidence interval) for incident NAFLD were 2.092 (1.458-3.002), 4.094 (2.942-5.698), 7.095 (5.167-9.742), and 13.191 (9.684-17.968) for participants with baseline ZJU index in quintiles 2-5, respectively. Further analysis found that the changes of ZJU index during follow-up was also independently associated with risk for incident NAFLD.ConclusionsBaseline ZJU index and absolute ZJU index changes independently predicts the risk for incident NAFLD in Chinese population.