Development of Retinal Amacrine Cells and Their Dendritic Stratification.
Development of Retinal Amacrine Cells and Their Dendritic Stratification.
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DOI：
10.1007/s40135-014-0048-2
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发表时间：
2014-09-01
影响因子：
0.9
通讯作者：
Gan L
中科院分区：
文献类型：
--
作者：
Balasubramanian R;Gan L
哺乳动物的视网膜包含多个神经元，每个神经元对视觉处理的贡献不同。在这些视网膜神经元中，无长突细胞最近受到关注，因为它们促进了视网膜中发生的大部分视觉处理。无长突细胞也是视网膜中最多样化的神经元群，主要根据它们表达的神经递质类型和树突乔木的形态进行分类。目前，人们对发育过程中这种多样性的分子基础知之甚少。无长突细胞还对内丛状层中的大部分突触做出贡献，并介导从双极细胞输入到视网膜神经节细胞的视觉信息。在这篇综述中，我们将描述目前对无长突细胞和细胞亚型发育的理解。此外，我们将探讨内丛状层视网膜分层的分子基础。总的来说，我们的综述将为无长突细胞亚型分类及其树突分层提供发展视角。
Themammalian retina containsmultiple neurons, each of which contributes differentially to visual processing. Of these retinal neurons, amacrine cells have recently come to prime light since they facilitate majority of visual processing that takes place in the retina. Amacrine cells are also the most diverse group of neurons in the retina, classified majorly based on the neurotransmitter type they express and morphology of their dendritic arbors. Currently, little is known about the molecular basis contributing to this diversity during development. Amacrine cells also contribute to most of the synapses in the inner plexiform layer and mediate visual information input from bipolar cells onto retinal ganglion cells. In this review, we will describe the current understanding of amacrine cell and cell subtype development. Furthermore, we will address the molecular basis of retinal lamination at the inner plexiform layer. Overall, our review will provide a developmental perspective of amacrine cell subtype classification and their dendritic stratification.