Cutaneous squamous cell carcinoma: Estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012
Cutaneous squamous cell carcinoma: Estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012
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DOI：
10.1016/j.jaad.2012.11.037
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发表时间：
2013-06-01
影响因子：
13.8
通讯作者：
Schmults, Chrysalyne D.
中科院分区：
文献类型：
--
作者：
Karia, Pritesh S.;Han, Jiali;Schmults, Chrysalyne D.
背景：据估计，在美国每年诊断出超过700，000例皮肤鳞状细胞癌（CSCC）新发病例。然而，CSCC已被排除在国家癌症登记册之外。因此，CSCC的确切发病率，沿着转移和死亡，导致it.Objective：我们试图估计2012年的发病率浸润性（非原位）CSCC和淋巴结转移和死亡的数量，它引起的美国白色population.Methods：美国研究报告的发病率CSCC，或淋巴结转移或死亡的数量，引起它，进行了审查。根据可用的发病率数据，采用线性回归估计当前CSCC的发病率，并对美国南部与北方/中部报告的较高发病率进行调整。报告的淋巴结转移和CSCC死亡的风险平均。根据发病率估计值，使用Approximation来估计当前的转移率和死亡率。估计的CSCC死亡人数与其他癌症死亡人数进行了比较。结果：据估计，2012年美国有186，157至419，543名白人被诊断为CSCC，5604至12，572名发生淋巴结转移，3932至8791名死于CSCC。2012年的发病率，淋巴结转移和死亡的估计浸润性CSCC的发病率和结果CSCC.Conclusion：CSCC是一个认识不足的健康问题的基础上以前的估计。在美国中部和南部，CSCC的死亡可能与肾癌和口咽癌以及黑色素瘤的死亡一样常见。需要报告CSCC发病率和结局的基于人群的研究来验证这些估计值。
Background: It is estimated that over 700,000 new cases of cutaneous squamous cell carcinoma (CSCC) are diagnosed annually in the United States. However, CSCC has been excluded from national cancer registries. Thus the precise incidence of CSCC, along with metastases and deaths resulting from it, is unknown.Objective: We sought to estimate the 2012 incidence of invasive (non-in situ) CSCC and the number of nodal metastases and deaths arising from it in the US white population.Methods: US studies reporting incidence of CSCC, or the number of nodal metastases or deaths arising from it, were reviewed. Linear regression was used to estimate current CSCC incidence based on available incidence data adjusting for higher reported incidences in southern versus northern/central United States. Reported risks of nodal metastases and death from CSCC were averaged. Averages were used to estimate current metastasis and death rates based on incidence estimates. The number of estimated CSCC deaths was compared against deaths from other cancers.Results: It is estimated that 186,157 to 419,543 whites were given a diagnosis of CSCC, 5604 to 12,572 developed nodal metastasis, and 3932 to 8791 died from CSCC in the United States in 2012.Limitations: The estimates of the 2012 incidence, nodal metastasis, and death from invasive CSCC are based on previous estimates of incidence and outcomes of CSCC.Conclusion: CSCC is an underrecognized health issue. In the central and southern United States, deaths from CSCC may be as common as deaths from renal and oropharyngeal carcinomas, and melanoma. Population-based studies reporting CSCC incidence and outcomes are required to verify these estimates.