Modular co-evolution of metabolic networks.
Modular co-evolution of metabolic networks.
复制标题
代谢网络的模块化协同进化
DOI：
10.1186/1471-2105-8-311
复制
发表时间：
2007-08-27
影响因子：
3
通讯作者：
Li, Yi-Xue
中科院分区：
文献类型：
--
作者：
Zhao, Jing;Ding, Guo-Hui;Tao, Lin;Yu, Hong;Yu, Zhong-Hao;Luo, Jian-Hua;Cao, Zhi-Wei;Li, Yi-Xue
生物网络的结构具有高度的模块性，网络的拓扑模块与已知的功能模块在一定程度上重叠。然而，分子网络的模块拓扑结构如何影响其成员蛋白质的进化仍不清楚。在这项工作中，智人（H。sapiens）代谢网络进行了研究。网络分解表明，代谢网络以高度模块化的核心-外围方式组织，核心模块紧密联系在一起，执行基本的代谢功能，而外围模块只与少数模块相互作用，完成相对独立和专门的功能。此外，超过一半的模块表现出协同进化的特征，属于特定的进化年龄。外围模块往往比核心模块发展得更快、更紧密。功能模块性、进化模块性和拓扑模块性之间的相关性表明，代谢系统的进化历史和功能要求已经烙印在代谢网络的架构中。这种系统水平的分析可以展示基因的进化如何被放置在基因组规模的网络环境中，为分子进化提供了一个新的视角。
The architecture of biological networks has been reported to exhibit high level of modularity, and to some extent, topological modules of networks overlap with known functional modules. However, how the modular topology of the molecular network affects the evolution of its member proteins remains unclear. In this work, the functional and evolutionary modularity of Homo sapiens (H. sapiens) metabolic network were investigated from a topological point of view. Network decomposition shows that the metabolic network is organized in a highly modular core-periphery way, in which the core modules are tightly linked together and perform basic metabolism functions, whereas the periphery modules only interact with few modules and accomplish relatively independent and specialized functions. Moreover, over half of the modules exhibit co-evolutionary feature and belong to specific evolutionary ages. Peripheral modules tend to evolve more cohesively and faster than core modules do. The correlation between functional, evolutionary and topological modularity suggests that the evolutionary history and functional requirements of metabolic systems have been imprinted in the architecture of metabolic networks. Such systems level analysis could demonstrate how the evolution of genes may be placed in a genome-scale network context, giving a novel perspective on molecular evolution.