POLYMERS CONTAINING ENZYMATICALLY DEGRADABLE BONDS .6. HYDROPHILIC GELS CLEAVABLE BY CHYMOTRYPSIN
POLYMERS CONTAINING ENZYMATICALLY DEGRADABLE BONDS .6. HYDROPHILIC GELS CLEAVABLE BY CHYMOTRYPSIN
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DOI：
10.1016/0142-9612(82)90004-7
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发表时间：
1982-01-01
期刊：
影响因子：
14
通讯作者：
KOPECEK, J
中科院分区：
文献类型：
--
作者：
ULBRICH, K;STROHALM, J;KOPECEK, J
以N-（2-羟丙基）甲基丙烯酰胺为交联剂，制备了含有寡肽序列的新型亲水凝胶。这些凝胶可被胰凝乳蛋白酶酶促降解。它们的降解速率可以通过改变交联中的寡肽序列的长度和详细结构以及通过改变它们的网络密度而在宽范围内变化。[这些聚合物可能具有作为植入材料或作为持续药物释放系统的基础的潜力。
New types of hydrophilic gels based on N-(2-hydroxypropyl)methacrylamide which contain oligopeptide sequences in the crosslinks were prepared. These gels are enzymatically degradable by chymotrypsin. The rate of their degradation may be varied within a broad range by changes in the length and detailed structure of the oligopeptide sequence in the crosslinks and by changing their network density. [These polymers may have potential as implant materials or as a basis for sustained drug release systems.].