Fission yeast cut mutations revisited: control of anaphase.
Fission yeast cut mutations revisited: control of anaphase.
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重新审视裂殖酵母切割突变：后期的控制。
DOI：
10.1016/s0962-8924(98)01236-7
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发表时间：
1998
影响因子：
19
通讯作者：
M. Yanagida
中科院分区：
文献类型：
--
作者：
M. Yanagida
细胞分裂后期的研究正进入一个黄金时期。几个不同的学科对我们理解细胞周期控制和有丝分裂过程中染色体和纺锤体动力学的进步做出了巨大贡献。本文介绍了控制后期的基础上获得的结果裂殖酵母粟酒裂殖酵母切割（细胞不合时宜撕裂）突变体。这些温度敏感的突变体分离的选择不协调的有丝分裂异常姐妹染色单体分离和后期事件。一些切割基因产物的表征导致鉴定与染色体凝聚、姐妹染色单体分离、后期促进蛋白水解、脂肪酸代谢和由应激或复制阻滞诱导的细胞周期阻滞相关的新分子事件。
Studies of anaphase are approaching a golden age. Several different disciplines have contributed immensely to advances in our understanding of cell-cycle control and chromosome and spindle dynamics during mitosis. This article describes control of anaphase based on results obtained fromSchizosaccharomyces pombe cut(cell untimely torn) mutants. These temperature-sensitive mutants were isolated by selection for uncoordinated mitosis with aberrant sister-chromatid separation and post-anaphase events. Characterization of some of the cut gene products has led to identification of novel molecular events related to chromosome condensation, sister-chromatid separation, anaphase-promoting proteolysis, fatty-acid metabolism, and cell-cycle arrest induced by stress or a replication block.
鉴定参与粟酒裂殖酵母有丝分裂的七个新切割基因。
影响因子：
4
作者：
Samejima,I;Matsumoto,T;Nakaseko,Y;Beach,D;Yanagida,M
通讯作者：
Yanagida,M