Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease
Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease
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DOI：
10.1017/s0007114508995660
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发表时间：
2009-01-01
影响因子：
3.6
通讯作者：
de Maat, Moniek P. M.
中科院分区：
文献类型：
--
作者：
Dalgard, Christine;Nielsen, Flemming;de Maat, Moniek P. M.
Inflammation and endothelial activation are associated with an increased risk of CVD and epidemiological evidence suggests an association between levels of markers of inflammation or endothelial activation and the intake of fruit. Also, vitamin E, a fat-soluble antioxidant, has anti-inflammatory properties. We performed a randomised 2 X 2 factorial, crossover trial to determine the effect of orange and blackcurrant juice (500 ml/d) and vitamin E (15 mg RRR-alpha-tocopherol/d) supplementation on markers of inflammation and endothelial activation in forty-eight patients with peripheral arterial disease. Patients were randomly allocated to two dietary Supplements from the four possible combinations of juice and vitamin E: juice + vitamin E; juice + placebo; reference beverage (sugar drink) + vitamin E; and reference beverage + placebo. The supplementations were given for 28d, separated by a 4-week wash-out period. Analysis of main effects showed that juice decreased C-reactive protein (CRP) by 11% and fibrinogen by 3% while the reference drink increased CRP by 13% and fibrinogen by 2% (P
