Epidemiology of HPV-Positive Tumors in Europe and in the World
Epidemiology of HPV-Positive Tumors in Europe and in the World
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DOI：
10.1007/978-3-319-43580-0_2
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Alemany, Laia
中科院分区：
文献类型：
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作者：
Castellsague, Xavier;Mena, Marisa;Alemany, Laia
在过去的15年里，已经积累了强有力的证据，表明某些人乳头瘤病毒（HPV）感染在病因学上与头颈癌（HNC）的一个子集有关。在本章中，对HNC的流行病学相关主题进行了综述：（i）HPV可归因分数和HPV类型在不同解剖学HNC部位的分布，不仅使用HPV DNA，还使用其他更具体的因果关系标志物;（ii）全球和各地区HPV相关HNC负担的更新;最后，（iii）HNC中HPV阳性的决定因素，重点关注性别、年龄、吸烟习惯、性行为以及扁桃体切除术表现等其他相关因素。这些信息对于了解疾病的负担及其动态和变化模式以及规划和评估基于HPV的预防策略对HNC的潜在影响至关重要。
Strong evidence has accumulated in the last 15 years showing that infection by certain human papillomaviruses (HPVs) is etiologically involved in a subset of head and neck cancers (HNCs). In this chapter, epidemiologic-related topics on HNCs are reviewed: (i) HPV-attributable fractions and HPV-type distributions by different anatomical HNC sites, using not only HPV DNA but other more specific markers of causality; (ii) an update of the HPV-related HNCs burden worldwide and by regions; and finally, (iii) the determinants for HPV positivity in HNCs, focussing on gender, age, smoking habits, sexual behavior, and other related factors such as tonsillectomy performance. This information is essential in order to understand the burden of the disease and its dynamics and changing patterns, as well as for planning and assessment of the potential impact of HPV-based preventive strategies for HNCs.