Does gastric bypass alter alcohol metabolism?
Does gastric bypass alter alcohol metabolism?
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DOI：
10.1016/j.soard.2007.07.003
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发表时间：
2007-09-01
影响因子：
3.1
通讯作者：
Morton, John M.
中科院分区：
文献类型：
--
作者：
Hagedorn, Judith C.;Encarnacion, Betsy;Morton, John M.
背景资料：病态肥胖是美国最主要的公共卫生危机，减肥手术是治疗这种疾病的唯一有效和持久的方法。已经提出了一个问题，即胃旁路术患者术后的酒精代谢可能会改变。我们假设，酒精代谢在术后胃旁路patient would be altered.Methods：在36名受试者，17名对照组和19名postgastric bypass受试者每人消耗5盎司的红葡萄酒。他们每5分钟进行一次酒精呼气分析。记录的结果包括症状，初始峰值酒精呼吸水平，和酒精呼吸水平的时间normalized.Results：胃旁路组平均年龄为10岁，有更大的体重和体重指数比对照组。胃旁路术后平均时间为2年，平均体重指数下降18 kg/m2（术前51 kg/m2，术后33 kg/m2）。胃旁路手术患者的酒精呼气峰值水平为0.08%，对照组为0.05%。胃旁路手术组平均需要108分钟才能达到0的酒精呼吸水平;对照组平均需要72分钟才能达到这一水平。两组表现出类似的postingesthetic symptoms profile.Conclusion：在这项研究中，酒精代谢显着不同的胃后分流术和对照组。虽然胃旁路术患者的酒精水平峰值更高，酒精水平达到0的时间也比对照组更长，但胃旁路术组并没有比对照组出现更多的症状。这些发现为胃旁路手术患者使用酒精提供了警告。(Surg肥胖相关疾病2007;3：543-548。(C)2007年美国代谢和减肥外科学会。All rights reserved.
Background: Morbid obesity is the leading public health crisis in the United States, with bariatric surgery as the only effective and enduring treatment for this disease. a concern has been raised, that, postoperatively, alcohol metabolism might be altered in gastric bypass patients. We hypothesized that alcohol metabolism in the postoperative gastric bypass patient would be altered.Methods: Of 36 subjects, 17 control and 19 postgastric bypass subjects each consumed 5 oz of red wine. They underwent an alcohol breath analysis every 5 minutes. The outcomes recorded included symptoms, initial peak alcohol breath level, and the time for alcohol breath levels to normalize.Results: The gastric bypass group was on average 10 years older and had a greater weight and body mass index than the control group. The average time after gastric bypass was 2 years, with an average body mass index loss of 18 kg/m(2) (51 kg/m(2) before versus 33 kg/m(2) after). The gastric bypass patients had a peak alcohol breath level of 0.08% and the controls had a level of 0.05%. The gastric bypass group needed, on average, 108 minutes to reach an alcohol breath level of 0; the control group reached this level after an average of 72 minutes. Both groups showed a similar postingestion symptom profile.Conclusion: In this study, alcohol metabolism was significantly different between the postgastric bypass and control subjects. Although the gastric bypass patients' had a greater peak alcohol level and a longer time for the alcohol level to reach 0 than the controls, the gastric bypass group did not experience more symptoms than the control group. These findings provide caution regarding alcohol use by gastric bypass patients. (Surg Obes Relat Dis 2007;3:543-548.) (C) 2007 American Society for Metabolic and Bariatric Surgery. All rights reserved.