Regulation of costimulation in the era of butyrophilins
Regulation of costimulation in the era of butyrophilins
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DOI：
10.1016/j.cyto.2009.03.009
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发表时间：
2009-06-01
期刊：
影响因子：
3.8
通讯作者：
Viney, Joanne L.
中科院分区：
文献类型：
--
作者：
Arnett, Heather A.;Escobar, Sabine S.;Viney, Joanne L.
在过去的几年中，由于观察到亲酪蛋白样2分子BTNL 2可以改变T细胞反应性，亲酪蛋白和亲酪蛋白样分子超家族在免疫学界引起了关注。在发现BTNL 2的遗传多态性与许多人类疾病的易感性相关之后，对这个超家族的额外兴趣得到了巩固。在这篇综述中，我们将提供一个概述的成员组成的butyrophilin超家族的分子。然后，我们将讨论BTNL2的免疫调节功能，以及BTNL2与其他共刺激分子的结构关联。然后，我们将通过描述这些分子在人体组织和细胞中的表达模式来提请您注意一些鲜为人知的butyrophilin超家族成员。最后，我们将通过假设对一般免疫稳态的潜在影响来结束，这种影响可能是由这个迄今为止很少研究的分子家族介导的。(C)2009爱思唯尔有限公司保留所有权利。
The butyrophilin and butyrophilin-like superfamily of molecules has garnered attention in the immunology world in the past few years as a result of the observation that the butyrophilin-like 2 molecule, BTNL2, can alter T cell responsiveness. Additional interest in this superfamily solidified following the discovery that genetic polymorphisms in BTNL2 are associated with predisposition to many human diseases. In this review, we will provide an overview of the members comprising the butyrophilin superfamily of molecules. We will then discuss BTNL2 immunomodulatory function, and BTNL2 structural associations with other costimulatory molecules. We will then draw your attention to some of the lesser-known butyrophilin superfamily members by describing the expression patterns of these molecules in human tissues and cells. And we will finish by hypothesizing on the potential influence on general immune homeostasis that might be mediated by this, thus-far little-studied, family of molecules. (C) 2009 Elsevier Ltd. All rights reserved.