Do dehydroepiandrosterone, progesterone, and testosterone influence women's depression and anxiety levels? Evidence from hair-based hormonal measures of 2105 rural Indian women.
Do dehydroepiandrosterone, progesterone, and testosterone influence women's depression and anxiety levels? Evidence from hair-based hormonal measures of 2105 rural Indian women.
复制标题
脱氢表雄酮、黄体酮和睾酮会影响女性的抑郁和焦虑水平吗？
DOI：
10.1016/j.psyneuen.2019.104382
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发表时间：
2019
影响因子：
3.7
通讯作者：
Berkman,L
中科院分区：
文献类型：
--
作者：
Walther,A;Tsao,C;Pande,R;Kirschbaum,C;Field,E;Berkman,L
抑郁症和焦虑症在很大程度上加重了全球疾病负担，特别是在贫穷国家。这两种疾病在女性中的患病率较高，表明性激素可能与这些疾病的病理生理学有关。Kshetriya Gramin Financial Services的研究调查了印度泰米尔纳德邦农村876个村庄的4160个家庭的随机样本。进行了访谈问卷调查，以量化抑郁（K6-D）和焦虑（K6-A）症状。此外，从2105名年龄在18-85岁之间的女性的子样本中收集了用于性激素分析的头发样本。重要的是，分别有5.9%、14.8%和46.3%的样本含有不可检测的脱氢表雄酮、孕酮和睾酮激素水平。我们的主要分析对不可检测样本的值进行插补，并在不可检测值下降时检查结果的稳健性。在这个来自印度农村的女性队列中，较高的抑郁症与较低的脱氢表雄酮水平相关，较高的抑郁和焦虑症状与较高的睾酮水平相关。预后与抑郁或焦虑症状无明显相关性。这些结果支持更高的内源性脱氢表雄酮水平的潜在保护作用。关于头发睾酮水平对女性心理健康的潜在负面影响的一个重要警告是，睾酮分析对如何处理不可检测的值很敏感。
Depressive and anxiety disorders substantially contribute to the global burden of disease, particularly in poor countries. Higher prevalence rates for both disorders among women indicate sex hormones may be integrated in the pathophysiology of these disorders. The Kshetriya Gramin Financial Services study surveyed a random sample of 4160 households across 876 villages in rural Tamil Nadu, India. An interviewer-administered questionnaire was conducted to quantify depressive (K6-D) and anxiety (K6-A) symptoms. Alongside, hair samples for sex hormone profiling were collected from a subsample of 2105 women aged 18–85 years. Importantly, 5.9%, 14.8%, and 46.3% of samples contained non-detectable hormone levels for dehydroepiandrosterone, progesterone, and testosterone, respectively. Our primary analysis imputes values for the non-detectable sample and we check robustness of results when non-detectable values are dropped. In this cohort of women from rural India, higher depressive symptomatology is associated with lower levels of dehydroepiandrosterone and higher depressive and anxiety symptoms are associated with higher levels of testosterone. Progesterone shows no clear association with either depressive or anxiety symptoms. These results support a potential protective effect of higher endogenous dehydroepiandrosterone levels. An important caveat on the potential negative effect of hair testosterone levels on women’s mental health is that the testosterone analysis is sensitive to how non-detectable values are treated.