Synthesis of chiral sultams with two adjacent stereocenters via palladium-catalyzed dynamic kinetic resolution
Synthesis of chiral sultams with two adjacent stereocenters via palladium-catalyzed dynamic kinetic resolution
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DOI：
10.1039/c7qo01098b
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发表时间：
2018-03
影响因子：
5.4
通讯作者：
B. Song;Mu-Wang Chen;Yong‐Gui Zhou
中科院分区：
文献类型：
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作者：
B. Song;Mu-Wang Chen;Yong‐Gui Zhou
通过动态动力学拆分，成功地发展了钯催化的分子内不对称还原胺化反应，得到了具有两个相邻立体异构中心的手性δ-磺内酰胺，具有高的非对映选择性和对映选择性.
A palladium-catalyzed intramolecular asymmetric reductive amination of racemic α-branched ketones bearing the poorly nucleophilic sulfonamides has been successfully developed through dynamic kinetic resolution, providing chiral δ-sultams with two contiguous stereogenic centers with high diastereoselectivity and enantioselectivity.