Quantification of the selective retention of palladium octabutoxynaphthalocyanine, a potential photothermal drug, in mouse tissues
Quantification of the selective retention of palladium octabutoxynaphthalocyanine, a potential photothermal drug, in mouse tissues
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DOI：
10.1016/s1011-1344(00)00108-1
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发表时间：
2000-11-01
影响因子：
5.4
通讯作者：
Weagle, G
中科院分区：
文献类型：
--
作者：
Bucking, M;Dickson, EFG;Weagle, G
八丁氧基萘二甲酸钯（PdNc（OBu）（8））是一种潜在的光热治疗（PTT）剂，在近红外区域吸收强烈，没有能力诱导光动力型敏化（不像许多相关的萘酞菁）。我们在此报告了高压液相色谱法（HPLC）与近红外吸收检测的应用，用于测定PdNc（OBu）（8）在荷瘤小鼠模型（患有EMT 6癌肿瘤的Balb/c小鼠）中的组织蓄积和清除。由于其在水基溶剂中的不溶性，该药物在含Cremophor的载体中腹膜内递送。与肌肉或皮肤相比，观察到药物在肿瘤中的良好选择性蓄积，选择性和肿瘤浓度的最佳组合发生在给药后24-72小时。清关时间很长。与文献中报道的其他类似药物的比较表明，含聚氧乙烯蓖麻油的溶媒可能在很大程度上导致了观察到的药代动力学行为。该药物显示出PTT的潜力，并将在该动物模型中进一步研究其治疗。(C)2000 Elsevier Science B. V.保留所有权利。
Palladium octabutoxynaphthalocyanine (PdNc(OBu)(8)) is a potential photothermal therapy (PTT) agent, absorbing strongly in the near-infrared region with no ability to induce photodynamic-type sensitisation (unlike many related napthalocyanines). We report here on the application of high pressure liquid chromatography (HPLC) with near-infrared absorption detection for the determination of the tissue accumulation and clearance of PdNc(OBu)(8) in a tumour-bearing mouse model (Balb/c mice with EMT6 carcinoma tumour). Due to its insolubility in aqueous-based solvents, the drug was delivered intraperitoneally in a Cremophor-containing vehicle. Good selective accumulation of the drug into the tumour versus muscle or skin is observed, with the best combination of selectivity and tumour concentration occurring at 24-72 h after drug administration. Clearance times are quite long. Comparison with other similar drugs as reported in the Literature indicates that the Cremophor-containing vehicle is likely in large part responsible for the observed pharmacokinetic behaviour. This drug shows potential for PTT and will be investigated further for therapy in this animal model. (C) 2000 Elsevier Science B.V. All rights reserved.