Different patterns of gray matter atrophy in early- and late-onset Alzheimer's disease
Different patterns of gray matter atrophy in early- and late-onset Alzheimer's disease
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DOI：
10.1016/j.neurobiolaging.2013.02.013
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发表时间：
2013-08-01
影响因子：
4.2
通讯作者：
van der Flier, Wiesje M.
中科院分区：
文献类型：
--
作者：
Moller, Christiane;Vrenken, Hugo;van der Flier, Wiesje M.
我们使用 3-Tesla 3D T1 加权磁共振成像，通过基于体素的形态测量，根据 215 名阿尔茨海默病 (AD) 患者和 129 名对照受试者的大样本，根据发病年龄评估了灰质萎缩模式。考虑到载脂蛋白 E 的影响，比较了晚发和早发 AD 患者与老年和年轻对照受试者之间的局部灰质量。此外，还评估了年龄和诊断对海马和楔前叶体积的综合影响。与年龄匹配的对照组相比，晚发AD患者表现出海马、右颞叶和小脑萎缩，而早发AD患者则表现出海马、颞叶、楔前叶、扣带回和额下皮层灰质萎缩。晚发性AD患者和早发性AD患者之间的直接比较显示，早发性AD患者的楔前叶萎缩更明显，晚发性AD患者的内侧颞叶萎缩更严重。年龄和诊断独立影响海马体；此外，年龄和诊断之间的相互作用表明，楔前叶萎缩在早发性 AD 患者中最为突出。我们的结果表明，AD 范围内的萎缩模式可能有所不同。 (c) 2013 Elsevier Inc. 保留所有权利。
We assessed patterns of gray matter atrophy according to-age-at-onset in a large sample of 215 Alzheimer's disease (AD) patients and 129 control subjects with voxel-based morphometry using 3-Tesla 3D T1-weighted magnetic resonance imaging. Local gray matter amounts were compared between late- and early-onset AD patients and older and younger control subjects, taking into account the effect of apolipoprotein E. Additionally, combined effects of age and diagnosis on volumes of hippocampus and precuneus were assessed. Compared with age-matched control subjects, late-onset AD patients exhibited atrophy of the hippocampus, right temporal lobe, and cerebellum, whereas early-onset AD patients showed gray matter atrophy in hippocampus, temporal lobes, precuneus, cingulate gyrus, and inferior frontal cortex. Direct comparisons between late- and early-onset AD patients revealed more pronounced atrophy of precuneus in early-onset AD patients and more severe atrophy in medial temporal lobe in late-onset AD patients. Age and diagnosis independently affected the hippocampus; moreover, the interaction between age and diagnosis showed that precuneus atrophy was most prominent in early-onset AD patients. Our results suggest that patterns of atrophy might vary in the spectrum of AD. (c) 2013 Elsevier Inc. All rights reserved.