Prognostic Significance of the Expression of CD98 (4F2hc) in Gastric Cancer
Prognostic Significance of the Expression of CD98 (4F2hc) in Gastric Cancer
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DOI：
10.21873/anticanres.11357
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发表时间：
2017-02-01
影响因子：
2
通讯作者：
Oyama, Tetsunari
中科院分区：
文献类型：
--
作者：
Satoh, Taisuke;Kaira, Kyoichi;Oyama, Tetsunari
背景：CD98 在多种人类肿瘤中高表达。然而，CD98表达与胃癌（GC）临床病理因素的关系尚不清楚。本研究检测了 CD98 表达及其对 GC 的临床病理学影响。患者和方法：对 331 名手术切除 GC 的患者进行了评估。使用免疫组织化学对肿瘤切片进行染色和分析以评估 CD98 表达。结果：CD98 在我们的患者队列中 19% (66/331) 呈阳性表达。 CD98表达增加与晚期GC分期、淋巴结转移、非印记组织学、淋巴渗透和血管侵犯显着相关。 CD98阳性表达也是术后不良预后的重要预测标志。然而，CD98 并未被确定为 GC 的独立预后预测因子。结论：CD98 可能是 GC 患者预后较差的新预测标志物。我们的数据表明，CD98 表达增加在肿瘤侵袭性和转移中起着重要作用。
Background: CD98 expression is high in various human neoplasms. However, the relationship of CD98 expression with the clinicopathological factors of gastric cancer (GC) remains unclear. This study examined CD98 expression and its clinicopathological impact on GC. Patients and Methods: Three hundred and thirty-one patients with surgically resected GC were evaluated. Tumor sections were stained and analyzed using immunohistochemistry to assess CD98 expression. Results: CD98 was positively expressed in 19% (66/331) of our patient cohort. Increased CD98 expression was significantly associated with advanced GC stage, lymph node metastasis, non-signet histology, lymphatic permeation, and vascular invasion. Positive CD98 expression was also a significant prediction marker for unfavorable prognosis postoperatively. However, CD98 was not identified as GC's independent prognostic predictor. Conclusion: CD98 could be a novel prediction marker for worse prognosis in GC-affected patients. Our data suggests that increased CD98 expression plays an essential role in tumor aggressiveness and metastasis.