EFFECT OF SODIUM VALPROATE ON MANIA - THE GABA-HYPOTHESIS OF AFFECTIVE-DISORDERS
EFFECT OF SODIUM VALPROATE ON MANIA - THE GABA-HYPOTHESIS OF AFFECTIVE-DISORDERS
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DOI：
10.1007/bf00343800
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发表时间：
1980-01-01
影响因子：
--
通讯作者：
WINDORFER, A
中科院分区：
文献类型：
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作者：
EMRICH, HM;VONZERSSEN, D;WINDORFER, A
通过使用双盲安慰剂对照 ABA 设计，在 5 名急性躁狂患者中检查了 GABA 能抗惊厥药丙戊酸盐可能的抗躁狂特性。 4 例患者在服用丙戊酸药物后观察到明显改善，而 1 例患者没有任何反应。另外 7 名经常反复发作的躁狂或蔓状分裂情感性精神病患者，对 Li 预防无反应，长期接受丙戊酸联合低剂量 Li 治疗（1 例仅使用丙戊酸）。在 1 1/2-3 年的观察期内，没有患者出现复发。显然，GABA 能抗惊厥药具有抗躁狂特性，Li 的特异性抗躁狂作用归因于 GABA 能作用模式。基于药物精神病学考虑，讨论了 GABA 系统在情感障碍和器质性精神病中的可能作用。
A possible antimanic property of the GABA-ergic anticonvulsant valproate was examined by use of a double-blind placebo-controlled ABA design in 5 acutely ill manic patients. In 4 cases a marked improvement was observed after valproate medication whereas 1 patient showed no response. Seven other patients with frequently recurrent episodes of a manic or maniform schizoaffective psychosis, irresponsive to Li prophylaxis, were chronically treated with valproate in combination with low doses of Li (1 case only with valproate). Over an observation period of 1 1/2-3 yr none of the patients exhibited a relapse. Apparently, GABA-ergic anticonvulsants possess antimanic properties and the specific antimanic effect of Li is due to a GABA-ergic mode of action. The possible role of GABA-systems in affective disorders and in organic types of psychoses is discussed on the basis of pharmacopsychiatric considerations.