Clinicopathologic characteristics of EGFR, KRAS, and ALK alterations in 6,595 lung cancers.
Clinicopathologic characteristics of EGFR, KRAS, and ALK alterations in 6,595 lung cancers.
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DOI：
10.18632/oncotarget.8074
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发表时间：
2016-04-26
期刊：
影响因子：
--
通讯作者：
Han J
中科院分区：
文献类型：
--
作者：
Lee B;Lee T;Lee SH;Choi YL;Han J
EGFR、KRAS和ALK改变是在非小细胞肺癌（NSCLC）中发现的主要遗传变化。检测晚期肺腺癌肿瘤的这三个基因现在是标准治疗。本研究的目的是探讨这三个基因在东亚非小细胞肺癌患者的临床病理表达模式。我们对2006年至2014年期间在韩国一家研究所检测这三种基因突变的所有患者进行了回顾性研究。研究数据从电子病历中提取。采用单变量和多变量logistic回归分析来衡量临床病理特征与EGFR、KRAS和ALK改变之间的相关性。我们检测到12例EGFR突变肿瘤，其中KRAS（N=6，0.1%）或ALK（N=6，0.1%）存在额外突变。EGFR、KRAS或ALK突变肿瘤的一般临床病理学特征与既往报告相似。携带EGFR L858R点突变的患者年龄大于携带EGFR 19号外显子缺失的患者。EGFR G719 X点突变在男性和吸烟者中比外显子19缺失或L858 R点突变更常见。具有KRAS G12C突变的肿瘤比具有G12D或G12V突变的肿瘤更不常见于粘液型。这是东亚NSCLC患者中最大的三基因分子流行病学研究。每一种遗传改变都与不同的临床病理特征相关。此外，不同的年龄和性别与EGFR和KRAS突变的不同亚型相关。
EGFR, KRAS, and ALK alterations are major genetic changes found in non-small cell lung cancers (NSCLCs). Testing advanced lung adenocarcinoma tumors for these three genes is now standard care. The purpose of this study was to investigate the clinicopathologic expression pattern of these three genes in East Asian NSCLC patients. We conducted a retrospective study of all patients tested for mutations of these three genes at a single institute in Korea between 2006 and 2014. Study data were extracted from electronic medical records. Univariate and multivariate logistic regression analyses were used to measure associations between clinicopathologic features and alterations of EGFR, KRAS, and ALK. We detected 12 EGFR-mutated tumors with additional mutations in KRAS (N=6, 0.1%) or ALK (N=6, 0.1%). General clinicopathologic characteristics of tumors with EGFR, KRAS, or ALK mutations were similar to previous reports. Patients having EGFR L858R point mutations were older than patients having EGFR exon 19 deletions. EGFR G719X point mutations were more common in men and smokers than exon 19 deletions or L858R point mutations. Tumors having KRAS G12C mutations were less often of mucinous type than those with G12D or G12V, mutations. This is the largest three gene molecular epidemiology study in East Asian NSCLC patients. Each genetic alteration was associated with distinct clinicopathologic characteristics. Furthermore, different age and sex are associated with different subtypes of EGFR and KRAS mutations.
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5.3
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