Effects of internal clock and memory disorders on duration reproductions and duration productions in patients with Parkinson's disease
Effects of internal clock and memory disorders on duration reproductions and duration productions in patients with Parkinson's disease
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DOI：
10.1016/j.bandc.2005.02.003
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发表时间：
2005-06-01
影响因子：
2.5
通讯作者：
Pouthas, V
中科院分区：
文献类型：
--
作者：
Perbal, S;Deweer, B;Pouthas, V
帕金森病（PD）患者表现出知觉和运动计时的缺陷以及与基底神经节中多巴胺能系统功能障碍相关的记忆和注意力过程的损伤。本研究的目的是评估PD患者的持续时间判断受损与记忆和注意力缺陷之间的关系。我们比较了药物PD患者和对照组的时间性能的持续时间的复制任务，是高度记忆依赖性的，并在持续时间的生产任务，可以揭示内部的时间保持机制的速度变化的影响。每个任务都是在控制计数条件下进行的，并且在需要在时间任务和并发阅读任务之间分配注意力的条件下进行。此外，PD患者和对照组的记忆和注意力进行了评估，使用电池的神经心理测试。结果表明，在复制任务的同时阅读条件下，PD患者的持续时间判断倾向于比对照组更易变。此外，变异的持续时间再现与记忆和疾病严重程度的措施。在产生任务的同时阅读条件下，PD患者的时距判断显著短于对照组，且时距产生的准确性与短时记忆的子测验得分相关。研究结果表明，多巴胺的管理并没有完全消除PD患者的记忆缺陷。此外，DA治疗会异常加速内部时钟的速率，导致PD患者的持续时间缩短。整个结果表明，患者的多巴胺给药可能掩盖了非药物PD患者通常报告的内部时钟的减慢速度，而没有完全恢复所有的记忆功能。(c)2005年爱思唯尔公司All rights reserved.
Patients with Parkinson's disease (PD) exhibit deficits in perceptual and motor timing as well as impairments in memory and attentional processes that are related to dysfunction of dopaminergic systems in the basal ganglia. The aim of the present study was to assess the relationships existing between impaired duration judgments and defective memory and attention in PD patients. We compared time performance of medicated PD patients and control subjects on a duration reproduction task that is highly memory-dependent, and on a duration production task that could reveal effects of changes in the speed of internal time-keeping mechanisms. Each task was performed in a control counting condition and in a condition requiring divided attention between the temporal task and a concurrent reading task. Moreover, PD patients and control subjects were assessed on memory and attention using a battery of neuropsychological tests. The results revealed that in the concurrent reading condition of the reproduction task, duration judgments tended to be more variable in PD patients than in control subjects. Moreover, variability of duration reproductions was correlated with both measures of memory and of disease severity. In the concurrent reading condition of the production task, duration judgments were significantly shorter in PD patients than in control subjects, and accuracy of duration productions was correlated with scores on sub-tests of short-term memory. The findings suggest that the administration of dopamine did not entirely remove the memory deficits in PD patients. Moreover, DA treatment would have abnormally accelerated the rate of the internal clock leading to shorter duration productions in PD patients. The whole results indicate that dopamine administration in patients might have overshadowed the slowing rate of the internal clock usually reported in non medicated PD patients, without entirely restoring all of the memory functions. (c) 2005 Elsevier Inc. All rights reserved.