Case Definitions, Diagnostic Algorithms, and Priorities in Encephalitis: Consensus Statement of the International Encephalitis Consortium
Case Definitions, Diagnostic Algorithms, and Priorities in Encephalitis: Consensus Statement of the International Encephalitis Consortium
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DOI：
10.1093/cid/cit458
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发表时间：
2013-10-15
影响因子：
11.8
通讯作者：
Consortium, Int Encephalitis
中科院分区：
文献类型：
--
作者：
Venkatesan, A.;Tunkel, A. R.;Consortium, Int Encephalitis
背景脑炎继续在全世界造成大量的发病率和死亡率。在诊断和管理方面的进展受到限制，部分原因是缺乏对病例定义、标准化诊断方法和研究优先事项的共识。2012年3月，国际脑炎联盟（International Encephalitis Consortium）在亚特兰大举行了一次会议，讨论脑炎的最新进展，并为未来的研究确定优先事项。我们提出了一个共识文件，提出了一个标准化的情况下的定义和诊断指南，以评估成人和儿童疑似脑炎。此外，研究的优先领域，包括宿主遗传学和选定的新出现的感染，进行了讨论。我们预计，这份文件是我们讨论的综合，并得到文献的支持，将为临床医生评估疑似脑炎患者提供实用帮助，并将确定关键领域和方法来提高我们对脑炎的认识。
Background. Encephalitis continues to result in substantial morbidity and mortality worldwide. Advances in diagnosis and management have been limited, in part, by a lack of consensus on case definitions, standardized diagnostic approaches, and priorities for research.Methods. In March 2012, the International Encephalitis Consortium, a committee begun in 2010 with members worldwide, held a meeting in Atlanta to discuss recent advances in encephalitis and to set priorities for future study.Results. We present a consensus document that proposes a standardized case definition and diagnostic guidelines for evaluation of adults and children with suspected encephalitis. In addition, areas of research priority, including host genetics and selected emerging infections, are discussed.Conclusions. We anticipate that this document, representing a synthesis of our discussions and supported by literature, will serve as a practical aid to clinicians evaluating patients with suspected encephalitis and will identify key areas and approaches to advance our knowledge of encephalitis.